A new approach to the synthesis of lamotrigine and other 3,5-diamino-1,2,4-triazine derivatives was written by Ulomskii, E. N.;Shestakova, T. S.;Deev, S. L.;Rusinov, V. L.;Chupakhin, O. N.. And the article was included in Russian Chemical Bulletin in 2005.HPLC of Formula: 3218-45-9 This article mentions the following:
A new in principle method for the synthesis of 6-aryl(hetaryl)-3,5-diamino-1,2,4-triazines by decomposition of pre-synthesized tetrazolo[1,5-b][1,2,4]triazines was developed. The advantages of this method over traditional methods were demonstrated using the synthesis of a modern antiepileptic preparation lamotrigine, as an example. The crystal structure of 6-phenyltetrazolo[1,5-b][1,2,4]triazin-7-amine is presented [monoclinic, space group P21/c, a 10.935(2), b 6.7330(10), c 13.279(3) Å, β 93.20(3)°, V 976.1(3) Å3, Z 4]. In the experiment, the researchers used many compounds, for example, 2-(2,3-Dichlorophenyl)acetonitrile (cas: 3218-45-9HPLC of Formula: 3218-45-9).
2-(2,3-Dichlorophenyl)acetonitrile (cas: 3218-45-9) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.HPLC of Formula: 3218-45-9
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts