Water-Soluble Iridium N-Heterocyclic Carbene Complexes for the Alkylation of Amines with Alcohols was written by Fernandes, Ana;Royo, Beatriz. And the article was included in ChemCatChem in 2017.Synthetic Route of C14H12N2 This article mentions the following:
A new series of water-soluble Ir complexes with N-heterocyclic carbene ligands that bearing ester and amide groups were obtained and fully characterized. The new complexes were highly reactive and selective for the alkylation of amines with alcs. with a 1:1 ratio of reactants in water and in the absence of base or other additives. The catalytic system had a broad substrate scope, which allowed the synthesis of a variety of primary and secondary amines in excellent yields. A tolerance to a large range of functional groups was obtained. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Synthetic Route of C14H12N2).
4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Synthetic Route of C14H12N2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts