Alkylation of Aromatic Amines with Trialkyl Amines Catalyzed by a Defined Iridium Complex with a 2-Hydroxypyridylmethylene Fragment was written by Deng, Danfeng;Hu, Bowen;Zhang, Ziyu;Mo, Shengkai;Yang, Min;Chen, Dafa. And the article was included in Organometallics in 2019.Category: nitriles-buliding-blocks This article mentions the following:
Six Cp*Ir complexes containing NN-bidentate chelate ligands [Cp*IrCl(C5H4CH2C5H3OH)][Cl] (1), [Cp*IrCl(C5H4CH2C5H3O)] (2), [Cp*IrCl(C5H4C5H3OH)] [Cl] (3), [Cp*IrCl(C5H4CH2C5H4)][Cl] (4), [Cp*IrCl(CH3OC5H3CH2C5H3OCH3)][Cl] (5), and [Cp*IrCl(CH3OC5H3CH2C5H3OH)][Cl] (6) were synthesized and characterized. Complex 1 could be transformed to 2 when reacted with NaOtBu or NEt3 via -OH deprotonation. These six complexes were tested as catalysts for mono-N-alkylation of amines with trialkyl amines, and complex 1 exhibited highest activity. The coupling reactions proceed under air condition, with 1 mol % catalyst loading without extra base in methanol at 120 °C and can be further accelerated by adding NR3·HCl. In the experiment, the researchers used many compounds, for example, 4-(Ethylamino)benzonitrile (cas: 4714-63-0Category: nitriles-buliding-blocks).
4-(Ethylamino)benzonitrile (cas: 4714-63-0) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts