Metal-Free Oxidation of Primary Amines to Nitriles through Coupled Catalytic Cycles was written by Lambert, Kyle M.;Bobbitt, James M.;Eldirany, Sherif A.;Kissane, Liam E.;Sheridan, Rose K.;Stempel, Zachary D.;Sternberg, Francis H.;Bailey, William F.. And the article was included in Chemistry – A European Journal in 2016.Computed Properties of C8H4F3NO This article mentions the following:
Synergism among several intertwined catalytic cycles allowed for selective, room temperature oxidation of primary amines to the corresponding nitriles in 85-98 % isolated yield. This metal-free, scalable, operationally simple method employed a catalytic quantity of 4-acetamido-TEMPO (ACT; TEMPO = 2,2,6,6-tetramethylpiperidine N-oxide) radical and the inexpensive, environmentally benign triple salt oxone as the terminal oxidant under mild conditions. Simple filtration of the reaction mixture through silica gel afforded pure nitrile products. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4Computed Properties of C8H4F3NO).
2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Computed Properties of C8H4F3NO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts