Makosza, Mieczyslaw published the artcileNitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides, SDS of cas: 87331-46-2, the main research area is vicarious nucleophilic substitution nitroarylamine preparation; nitroarylamine preparation; arylamine nitro preparation; amination nitroarene sulfenamide.
A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of amination.
Journal of Organic Chemistry published new progress about Amination. 87331-46-2 belongs to class nitriles-buliding-blocks, name is 2-Amino-3-nitrobenzonitrile, and the molecular formula is C7H5N3O2, SDS of cas: 87331-46-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts