Month: December 2022

Shimoda, Yoko published the artcileSynthesis and Evaluation of Novel Radioligands Based on 3-[5-(Pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor Subtype 5, Recommanded Product: 3-Amino-5-methoxybenzonitrile, the main research area is pyridinyltetrazolylbenzonitrile radioligand preparation positron emission tomog; benzonitrile metabotropic glutamate receptor subtype 5 binding affinity lipophility.

We found out 3-[5-(pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile analogs as the candidate for positron emission tomog. (PET) imaging agents of metabotropic glutamate receptor subtype 5 (mGluR5). Among these compounds, 3-methyl-5-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)benzonitrile (I, X = CH3) exhibited high binding affinity (Ki = 9.4 nM) and moderate lipophilicity (cLogD, 2.4). Subsequently, I (X = 11CH3) was radiosynthesized at 25 ± 14% radiochem. yield (n = 11) via C-[11C]methylation of the arylstannyl precursor 15 with [11C]methyl iodide. In vitro autoradiog. and PET assessments using I (X = 11CH3) showed high specific binding in the striatum and hippocampus, two brain regions enriched with mGluR5. Moreover, test-retest PET studies with I (X = 11CH3) indicated high reliability to quantify mGluR5 d., such as the intraclass correlation coefficient (0.90) and Pearson r (0.91) in the striatum of rat brain. We demonstrated that I (X = 11CH3) is a useful PET ligand for imaging and quant. anal. of mGluR5. Furthermore, I (X = 11CH3) might be modified using its skeleton as a lead compound

Journal of Medicinal Chemistry published new progress about Brain. 269411-71-4 belongs to class nitriles-buliding-blocks, name is 3-Amino-5-methoxybenzonitrile, and the molecular formula is C8H8N2O, Recommanded Product: 3-Amino-5-methoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Azim Araghi, Mohammad Esmaeil published the artcileOptical, electrical, and gas sensing properties of chloroaluminium phthalocyanine thin film, Name: Phthalonitrile, the main research area is chloroaluminum phthalocyanine thin film optical elec gas sensing property.

In this research work, the optical, elec., and gas sensing properties of Chloroaluminum Phthalocyanine (ClAlPc) thin film have studied. We fabricated sandwich devices of ClAlPc with aluminum electrodes as Al/ClAlPc/Al, using evaporation deposition method in our Laboratory SEM anal. was carried out to determine the morphol., grains size and thickness of ClAlPc thin film. UV-vis anal. of thin film indicated B and Q absorption bands of ClAlPc, and its optical band gap was then calculated 3.24 eV. The current-voltage characteristic (I-V) of sandwich devices at different temperatures proved the ohmic and SCLC processes in the ClAlPc thin film. By plotting the LnI vs. 1000/T graph, the elec. band gap of ClAlPc was obtained 2.88 eV. In the finally section, the gas sensing behavior of sandwich devices in the presence of CO2 was investigated. To determine the temperature of maximum sensitivity (Tmax), the devices were exposed to CO2 gas over the temperature range 300-450 K at a fixed voltage. We found that Tmax = 360 K.

Optik (Munich, Germany) published new progress about Diodes. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Name: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bouaik, Hassan published the artcileOptimal parameters and structural composition of bio-oil and biochar from intermediate pyrolysis of red algal biomass, Safety of Picolinonitrile, the main research area is bio oil biochar nitrogen carbon biomass pyrolysis.

Intermediate pyrolysis of red algal biomass was performed in a fixed-bed tubular reactor. To study the parametric effect on product distribution, the experiments were carried out at different temperatures ranging from 400 to 600 °C and different heating rates of 15, 30 and 50 °C/min. The objective of this study is to understand the effect of pyrolysis temperature and heating rate on the yields and compositions of the pyrolysis products of red algal biomass. The bio-oil, biochar and biogas yields ranged between 33 and 45 wt%, 29 and 42 wt%, and 18 and 35 wt%, resp., at different pyrolysis conditions. The highest bio-oil yield (45.02%) was obtained at 450 °C temperature at a heating rate of 50 °C/min. The bio-oil was characterized by proximate and ultimate anal., FTIR, 1H-NMR and GC-MS anal. whereas the biochar was characterized by proximate, ultimate, FTIR, SEM and BET. Higher heating value and d. of the bio-oil were 20.11 MJ/kg, 1289 kg/m3, resp. The bio-oil with relatively high fuel potential can be obtained from the pyrolysis of the red algal biomass. The characterization of bio-oil showed a high percentage of aliphatic functional groups and presence of phenolic, ketone- and nitrogen-containing groups. The characterization results showed that the bio-oil obtained from red algal biomass can be potentially valuable as a source of value-added chems. The biochar obtained with a high heating value of 22.89 MJ/kg can be used as an adsorbent as well as a solid fuel.

Comptes Rendus Chimie published new progress about Biogas. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Otlyotov, Arseniy A. published the artcileGas-phase structures of hemiporphyrazine and dicarbahemiporphyrazine: Key role of interactions inside coordination cavity, Quality Control of 91-15-6, the main research area is hemiporphyrazine dicarbahemiporphyrazine moleclular structure electron diffraction hydrogen bond.

The structures of free hemiporphyrazine and dicarbahemiporphyrazine mols. were determined by gas-phase electron diffraction and DFT calculations Distance corrections (re – ra) were calculated using two different approaches: commonly applied Sipachev’s algorithm and a recently developed technique based on mol. dynamics simulations. Both approaches examined against each other for the first time in the refinement of a relatively large (52 atoms) structure were found to result in almost the same final structural parameters. Gas-phase structures of hemiporphyrazine and dicarbahemiporphyrazine are saddle distorted, in contrast to the planar structure previously found for the solid-state hemiporphyrazine. Doubly charged anionic form of hemiporphyrazine was calculated to be significantly saddle distorted, while the anion of dicarbahemiporphyrazine was determined to possess a planar equilibrium structure. Structural features of the mols. and their doubly charged anionic forms are discussed in terms of AIM and NBO analyses.

Journal of Molecular Structure published new progress about Anions. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Quality Control of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Strauss, Marie E. published the artcileValence-, Dipole- and Quadropole-Bound Electronically Excited States of Closed-Shell Anions Formed by Deprotonation of Cyano- and Ethynyl-Disubstituted Polycyclic Aromatic Hydrocarbons, Formula: C8H4N2, the main research area is dicyanobenzene naphthalene electronic state astrochem.

Dicyano-functionalized benzene and naphthalene anion derivatives exhibit a relatively rich population of electronically excited states in stark contrast to many assumptions regarding the photophysics of anions in general. The present work has quantum chem. analyzed the potential electronically excited states of closed-shell anions created by replacing hydrogen atoms with valence-bound lone pairs in benzene and naphthalene difunctionalized with combinations of -CN and -C2H. Dicyanobenzene anion derivatives can exhibit dipole-bound excited states as long as the cyano groups are not in para position to one another. This also extends to cyanoethynylbenzene anions as well as deprotonated dicyano- and cyanoethynylnaphthalene anion derivatives Diethynyl functionalization is less consistent. While large dipole moments are created in some cases for deprotonation on the -C2H group itself, the presence of electronically excited states beyond those that are dipole-bound is less consistent. Beyond these general trends, 2-dicyanonaphthalene-34 gives strong indication for exhibiting a quadrupole-bound excited state, and the 1-cyanoethynylnaphthalene-29 and -36 anion derivatives are shown to possess as many as two valence-bound excited states and one dipole-bound excited state. These photophys. properties may have an influence on regions where polycyclic aromatic hydrocarbons are known to exist such as in various astrochem. environments or even in combustion flames.

Chemistry (Basel, Switzerland) published new progress about Anions. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rani, Anu published the artcile1H-1,2,3-triazole grafted tacrine-chalcone conjugates as potential cholinesterase inhibitors with the evaluation of their behavioral tests and oxidative stress in mice brain cells, SDS of cas: 1885-29-6, the main research area is triazole grafted tacrine chalcone conjugate cholinesterase inhibitor oxidative stress; 1H-1,2,3-triazole-tacrine-chalcone; Alzheimer’s disease; An Acetylcholinesterase inhibitor; Behavioral models; Butyrylcholinesterase inhibition; Molecular docking; Oxidative stress parameters.

The present paper explicates the synthesis of 1H-1,2,3-triazole tethered tacrine-chalcone conjugates and evaluation of their AChE and BuChE inhibitory activity. In-vitro AChE inhibition assay revealed three compounds, 9h, 9i, and 11f, being more potent than the standard drug tacrine and further evaluated against butyrylcholinesterase. The present study was extended to investigate the anti-amnestic effect of promising compounds on scopolamine-induced behavioral and neurochem. changes in mice. Inclined plane model and Elevated plus-maze model were performed to assess general limb motor activity and anxiety-like behavior, resp., in mice pre-treated with scopolamine. Oxidative stress parameters reduced glutathione contents (GSH) and lipid peroxidation products (TBARS) in the brain homogenates as estimated using ex-vivo studies. Furthermore, mol. docking studies were performed for the potent compounds to decipher the mechanism of observed activities.

Bioorganic Chemistry published new progress about Anxiety. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kilic, Hulya A. published the artcileSelective glucose dehydration over novel metal phthalocyanine catalysts at low temperatures, Quality Control of 91-15-6, the main research area is glucose dehydration HMF metal phthalocyanine catalyst.

In this report, promising carbon-based novel metal phthalocyanine catalysts were prepared and tested in glucose dehydration at low temperatures (90-130°C) under atm. conditions. Most of the prepared phthalocyanines exhibited high conversions in dimethylsulfoxide (DMSO). A complete conversion of glucose was obtained over Aluminum phthalocyanine (AlPcCl) and Tin phthalocyanine (SnPcCl2) catalysts. AlPcCl also provided the highest HMF yield (53% in 3 h at 130°C). Al3+ cations promoted the glucose conversion and Cl- anions played an active role in 5-Hydroxymethylfurfural (5-HMF) formation. Dimethylsulfoxide (DMSO) as a solvent, was also found effective with phthalocyanines for high 5-HMF yield by stabilizing its structure. Thus, the 5-HMF yield was observed high (53.0% at 130°C for 3 h) over AlPcCl in DMSO. Kinetic studies showed that the optimum reaction temperature was 130°C at 1/5 catalyst/glucose ratio for 3 h. Dehydration reactions, performed in the aqueous phase, exhibited higher fructose selectivities with AlPcCl catalyst.

Reaction Kinetics, Mechanisms and Catalysis published new progress about Acidity. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Quality Control of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Challa, Prathap published the artcileCoupling of CH3OH and CO2 with 2-cyanopyridine for enhanced yields of dimethyl carbonate over ZnO-CeO2 catalyst, Safety of Picolinonitrile, the main research area is methanol carbon dioxide cyanopyridine dimethyl carbonate.

The present work is aimed to produce di-Me carbonate by coupling of CH3OH and CO2 with 2-cyanopyridine over ZnO-CeO2 catalysts prepared by co-precipitation method. These catalysts were characterized by XRD, TEM, UV-Vis DRS, BET surface area, CO2 and NH3-TPD techniques and applied for the titled reaction. Among the investigated catalysts 10ZnO-90CeO2 catalyst with CeO2 crystallite size 8.0 nm exhibited 96% conversion of methanol with 99% selectivity to di-Me carbonate. The superior catalytic activity is a unified effect of crystalline size of CeO2 and presence of an optimum number of acidic and basic sites. This protocol offers enhanced conversion of methanol with the simultaneous conversion of 2-cyanopyridine into 2-picolinamide by removing water mols. formed in the reaction.

Journal of Chemical Sciences (Berlin, Germany) published new progress about Acidity. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dong, Yansong published the artcileA General Strategy for Macrotheranostic Prodrug Activation: Synergy between the Acidic Tumor Microenvironment and Bioorthogonal Chemistry, Quality Control of 100-70-9, the main research area is prodrug tumor pH imaging; bioorthogonal chemistry; cancer; drug delivery; photodynamic therapy; self-assembly.

Prodrugs activated by endogenous stimuli face the problem of tumor heterogeneity. Bioorthogonal prodrug activation that utilizes an exogenous click reaction has the potential to solve this problem, but most of the strategies currently used rely on the presence of endogenous receptors or overexpressed enzymes. We herein integrate the acidic, extracellular microenvironment of a tumor and a click reaction as a general strategy for prodrug activation. This was achieved by using a tumor pH-responsive polymer containing tetrazine groups, which formed unreactive micelles in the blood but disassembled in response to tumor pH. The vinyl ether group on the macrotheranostic prodrug (CyPVE) is activated by the tetrazine groups, which was confirmed by tumor-specific fluorescence activation and phototoxicity restoration. Therefore, the bioorthogonal reactions in the context of the ubiquitous acidic tumor microenvironment can provide a general strategy for bioorthogonal prodrug activation.

Angewandte Chemie, International Edition published new progress about Acidity. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Senapati, Rabinarayan published the artcileA Versatile VMPO Catalyst Prepared In Situ for Oxidative Ammonolysis of Isomeric Picolines and Xylenes, Related Products of nitriles-buliding-blocks, the main research area is picoline xylene oxidative ammonolysis vanadomolybdophosphoric acid supported titania catalyst.

The V2O5-MoO3-P2O5 (VMPO) catalyst has been prepared in situ by thermal decomposition of vanado-molybdophosphoric acid (PMoV) on TiO2 support at 475°C. The TiO2 supported VMPO catalysts are characterized by FT-IR, XRD, BET surface area, NH3-TPD, and H2-TPR. Morphol. of the catalyst has been studied by TEM. The accumulated data indicate decomposition of PMoV and presence of phosphate and pyrophosphate phases of molybdenum and vanadium after calcination. TPD and TPR studies exhibit the moderate acidity and presence of V4+ in the material, resp. The VMPO catalyst has been used for ammoxidation of six different compounds including three isomeric picolines and three isomeric xylenes to the corresponding nitriles with the yield of 90-96%.

Russian Journal of General Chemistry published new progress about Acidity. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts