Month: December 2022

Beaulieu, Normand published the artcileLiquid chromatographic determination of ketoprofen and its related compounds in raw materials, capsules, and enteric coated tablets, Formula: C16H13NO, the main research area is ketoprofen impurity determination liquid chromatog.

A liquid chromatog. method for the determination of ketoprofen and 6 known related compounds was developed. The lower limit of quantitation of the related compounds in the drug is 0.05% or less for all compounds, and the precision of the drug assay method is �.5%. The highest levels of impurities found in 3 drug raw material samples and 4 solid oral dosage formulations were 1.37 and 0.43%, resp.

Journal – Association of Official Analytical Chemists published new progress about ketoprofen impurity determination liquid chromatog. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Formula: C16H13NO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jie, Zhou published the artcileDiethyl Chlorophosphite: A Versatile Reagent, Recommanded Product: 2,3-Dimethoxybenzonitrile, the main research area is diethyl chlorophosphite reaction oxygenated functional group.

Di-Et chlorophosphite (DECP) was previously described as a reducing agent for nitro compounds to amines (B. Fischer and L. Sheihet, J. Organic Chem. 1998, 63, 393). Here, the utility of this reagent was extended to chem. conversions of other oxygenated functional groups. In this paper we report on the scope of the reaction of DECP with N-oxides, epoxides, sulfones, sulfoxides, hydroxylamines, ketoximes, and aldoximes. The chemoselectivity of DECP is described, and conditions for a stepwise multiple conversion of functional groups on the same mol. with this reagent are provided.

Journal of Organic Chemistry published new progress about diethyl chlorophosphite reaction oxygenated functional group. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Recommanded Product: 2,3-Dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Al-Rubaie, Ali Z. published the artcilePalladium-catalyzed formation of 3,5-diaryl-1,2,4-selenadiazoles from arylselenocarboxamide, COA of Formula: C9H9NO2, the main research area is diarylselenadiazole preparation; arylselenocarboxamide preparation cyclization; selenadiazole diaryl preparation.

A number of new and known arylselenocarboxamides RC(:Se)NH2 [R = Ph, 4-BrC6H4, 2-MeOC6H4, 4-MeOC6H4, 4-MeSC6H4, 4-EtOC6H4, 2,3-(MeO)2C6H3, 3,4-(MeO)2C6H3, 3,5-(MeO)2C6H3, 4-PhC6H4, 6-MeOC10H6, 4-MeOC10H6] have been prepared in high yields by the reaction of RCN with NaHSe. Treatment of RC(:Se)NH2 (4 mmol) with aqueous Na2PdCl4 (1 mmol) in acetone at room temperature resulted in the formation of 3,5-diaryl-1,2,4-selenadiazoles (L) as unexpected products together with palladium(II) complexes [PdCl2L]2.2H2O. Treatment of RC(:Se)NH2 (4 mmol) with catalytic amounts of Na2PdCl4 (10-3 mmol) gave only 3,5-diaryl-1,2,4-selenadiazoles in good yields. 3,5-Diaryl-1,2,4-selenodiazoles were also prepared by oxidation of arylselenocarboxamides with iodine for comparison.

Journal of Organometallic Chemistry published new progress about diarylselenadiazole preparation; arylselenocarboxamide preparation cyclization; selenadiazole diaryl preparation. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, COA of Formula: C9H9NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hatano, Kouta published the artcileSyntheses of 2,4-dicyanophenoxyacetic acid and its analogs, Category: nitriles-buliding-blocks, the main research area is cyanophenoxyacetate pesticide; phenoxyacetate cyano pesticide.

Cyanophenoxyacetic acids (I; R = H; R1 = H, CN; R2 = Me, H, CN) and their Et esters (I; R = Et) were prepared in order to test their pesticidal properties. E.g. Reimer-Tiemann reaction of o-HOC6H4CHO, followed by refluxing the resulting 2,4-(OHC)2C6H3OH with NH2OH.HCl in AcOH gave 2,4-(NC)2C6H3OH which reacted with BrCH2CO2Et to give I (R = Et, R1 = R2 = CN). The other I were prepared similarly.

Agricultural and Biological Chemistry published new progress about cyanophenoxyacetate pesticide; phenoxyacetate cyano pesticide. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yang, Yong published the artcileComplete chloroplast genome sequence of the mangrove species Kandelia obovata and comparative analyses with related species., Recommanded Product: Phthalonitrile, the main research area is Chloroplast genome; Kandelia obovata; Mangrove species; Phylogeny comparative analysis.

As one of the most cold and salt-tolerant mangrove species, Kandelia obovata is widely distributed in China. Here, we report the complete chloroplast genome sequence K. obovata (Rhizophoraceae) obtained via next-generation sequencing, compare the general features of the sampled plastomes of this species to those of other sequenced mangrove species, and perform a phylogenetic analysis based on the protein-coding genes of these plastomes. The complete chloroplast genome of K. obovata is 160,325 bp in size and has a 35.22% GC content. The genome has a typical circular quadripartite structure, with a pair of inverted repeat (IR) regions 26,670 bp in length separating a large single-copy (LSC) region (91,156 bp) and a small single-cope (SSC) region (15,829 bp). The chloroplast genome of K. obovata contains 128 unique genes, including 80 protein-coding genes, 38 tRNA genes, 8 rRNA genes and 2 pseudogenes (ycf1 in the IRA region and rpl22 in the IRB region). In addition, a simple sequence repeat (SSR) analysis found 108 SSR loci in the chloroplast genome of K. obovata, most of which are A/T rich. IR expansion and contraction regions were compared between K. obovata and five related species: two from Malpighiales and three mangrove species from different orders. The mVISTA results indicated that the genome structure, gene order and gene content are highly conserved among the analyzed species. The phylogenetic analysis using 54 common protein-coding genes from the chloroplast genome showed that the plant most closely related to K. obovata is Ceriops tagal of Rhizophoraceae. The results of this study provide useful molecular information about the evolution and molecular biology of these mangrove trees.

PeerJ published new progress about Chloroplast genome; Kandelia obovata; Mangrove species; Phylogeny comparative analysis. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Okunrintemi, Victor published the artcileSex Differences in the Age of Diagnosis for Cardiovascular Disease and Its Risk Factors Among US Adults: Trends From 2008 to 2017, the Medical Expenditure Panel Survey., Recommanded Product: Picolinonitrile, the main research area is age of diagnosis; cardiovascular disease; risk factors; sex differences.

Background Sex differences in the trends for control of cardiovascular disease (CVD) risk factors have been described, but temporal trends in the age at which CVD and its risk factors are diagnosed and sex-specific differences in these trends are unknown. Methods and Results We used the Medical Expenditure Panel Survey 2008 to 2017, a nationally representative sample of the US population. Individuals â‰?8 years, with a diagnosis of hypercholesterolemia, hypertension, coronary heart disease, or stroke, and who reported the age when these conditions were diagnosed, were included. We included 100 709 participants (50.2% women), representing 91.9 million US adults with above conditions. For coronary heart disease and hypercholesterolemia, mean age at diagnosis was 1.06 and 0.92 years older for women, compared with men, respectively (both P<0.001). For stroke, mean age at diagnosis for women was 1.20 years younger than men (P<0.001). The mean age at diagnosis of CVD risk factors became younger over time, with steeper declines among women (annual decrease, hypercholesterolemia [women, 0.31 years; men 0.24 years] and hypertension [women, 0.23 years; men, 0.20 years]; P<0.001). Coronary heart disease was not statistically significant. For stroke, while age at diagnosis decreased by 0.19 years annually for women (P=0.03), it increased by 0.22 years for men (P=0.02). Conclusions The trend in decreasing age at diagnosis for CVD and its risk factors in the United States appears to be more pronounced among women. While earlier identification of CVD risk factors may provide opportunity to initiate preventive treatment, younger age at diagnosis of CVD highlights the need for the prevention of CVD earlier in life, and sex-specific interventions may be needed. Journal of the American Heart Association published new progress about age of diagnosis; cardiovascular disease; risk factors; sex differences. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Teyateeti, Ajalaya published the artcileSurvival outcomes for yttrium-90 transarterial radioembolization with and without sorafenib for unresectable hepatocellular carcinoma patients, Application of Phthalonitrile, the main research area is 90Y; TheraSphere; adverse events; prognostic factors; selective internal radiation therapy.

Purpose: To assess the overall survival (OS) and progression-free survival (PFS) of unresectable hepatocellular carcinoma (HCC) patients undergoing yttrium-90 glass-microsphere transarterial radioembolization (TARE) with and without concurrent sorafenib. Methods: OS and PFS were analyzed in 55 patients with an intrahepatic tumor (IHT) �0% without advanced or aggressive disease features (ADFs), which was referred to presence of infitrative/ill-defied HCC, macrovascular invasion, or extrahepatic disease treated with only TARE (TARE_alone) and in 74 patients with IHT �0% with ADFs or IHT >50% treated with TARE and sorafenib (TARE_sorafenib). Prognostic factors for OS and PFS were identified using univariate and multivariate analyses. Results: Median OS and PFS of TARE_alone patients were 21.6 (95% CI 6.1-37.1) and 9.1 (95% CI 5.2-13.0) months, resp., and for TARE_sorafenib patients 12.4 (95% CI 9.1-15.6) and 5.1 (95% CI 2.6-7.5) months, resp. Better OS was associated with serum AFP <400 (HR 0.27, p=0.02) in TARE_alone, and IHT �0% (HR 0.39, p=0.004) and AFP <400 (HR 0.5, p=0.027) in TARE_sorafenib. Unilobar involvement (HR 0.43, p=0.029) and AFP <400 ng/mL (HR 0.52, p=0.015) correlated with better PFS in TARE_alone and TARE_sorafenib, resp. Adverse events (AEs) were more frequent in TARE_sorafenib than TARE_alone (92.4 vs 80.3%), but only 9.3% were grade 3 or higher AEs. Conclusion: TARE_alone provided the most prominent survival benefit in IHT �0%- without ADF patients who had unilobar HCC and serum AFP <400 ng/mL. TARE and sorafenib yielded the best outcomes in patients with IHT �0% and serum AFP <400 ng/mL, with some addnl. grade 1-2 AEs compared to TARE only. Journal of Hepatocellular Carcinoma published new progress about 90Y; TheraSphere; adverse events; prognostic factors; selective internal radiation therapy. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Xiao-Fei published the artcileβ-Cyclodextrin-conjugated phthalocyanines as water-soluble and recyclable sensitizers for photocatalytic applications, Category: nitriles-buliding-blocks, the main research area is cyclodextrin conjugated phthalocyanines water soluble recyclable sensitizer photocatalyst.

Two zinc(II) phthalocyanines substituted with two and four permethylated β-cyclodextrin moieties at the α positions have been synthesized and immobilized on the surface of adamantane-modified silica nanoparticles through host-guest interactions. These mol. and supramol. systems can catalyze the photooxygenation of 1-naphthol and 2-furoic acid in organic and aqueous media with high conversion efficiency and reaction yield, and photodegradation of 2-chlorophenol in water. Having a higher photostability and recyclability, the supramol. nanosystems are particularly promising for these photocatalytic applications.

Chemical Communications (Cambridge, United Kingdom) published new progress about Air. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Martin, Rainer E. published the artcileSynthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2), Recommanded Product: 4-(5-Oxazolyl)benzonitrile, the main research area is cyclopentapyridine cyclohexapyridine preparation SAR aldosterone synthase inhibitory; continuous flow Kondrateva reaction.

A series of cyclopenta[c]pyridine aldosterone synthase (AS) inhibitors were conveniently accessed using batch or continuous flow Kondrat’eva reactions. Preparation of the analogous cyclohexa[c]pyridines, e. g., I, led to the identification of a potent and more selective AS inhibitor. The structure-activity-relationship (SAR) in this new series was rationalized using binding mode models in the crystal structure of AS.

Organic & Biomolecular Chemistry published new progress about Flow. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Recommanded Product: 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Yuting published the artcileSynthesis and Properties of Benzoxazine Monomers Bearing Both 3-Methyltetrahydrophtalimide and Nitrile Groups: Para-Para vs. Ortho-Ortho, Synthetic Route of 1885-29-6, the main research area is methytetrahydrophtalimide nitrile functionalized benzoxazine polymerization thermomech flame retardant property.

Two 3-methytetrahydrophtalimide-functional benzoxazine monomers containing nitrile group have been prepared in order to achieve the basic design rules for developing high-performance thermosets via multifunctional benzoxazines. The chem. structures of the two new synthesized benzoxazine monomers have been confirmed by 1H NMR, 13C NMR and FT-IR. Besides, the polymerization behavior has been studied by using DSC and in situ FT-IR. In addition, the thermal stability and flame retardant properties of the resulting polybenzoxazines have also been investigated using TGA and MCC. The polybenzoxazine based on ortho-3-methytetrahydrophtalimide functional benzoxazine containing ortho-nitrile group exhibits excellent thermal stability and low flammability, with a Td10 of 378°C and a HRC value of 180 J/(g K).

Macromolecular Research published new progress about Chars. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts