Month: December 2022

Sato, Takahiro published the artcileDiscovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 – a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia, HPLC of Formula: 135048-32-7, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(21), 6225-6229, database is CAplus and MEDLINE.

A previous study identified 2-[2-(2-methoxy-ethoxy)-ethoxy]-5-[5-(2-methyl-4-pyridyl)-1H-[1,2,4]triazol-3-yl]-benzonitrile as a safe and potent xanthine oxidoreductase (XOR) inhibitor for the treatment of hyperuricemia. A series of 3,5-dipyridyl-1,2,4-triazole derivatives were synthesized and their in vivo activity in lowering the serum uric acid levels in rats was examined As a result, 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole (FYX-051) to be one of the most potent XOR inhibitors; it exhibited an extremely potent in vivo activity, weak CYP3A4-inhibitory activity and a better pharmacokinetic profile than the previously identified compound FYX-051 is currently being evaluated in a phase 2 clin. trial.

Bioorganic & Medicinal Chemistry Letters published new progress about 135048-32-7. 135048-32-7 belongs to nitriles-buliding-blocks, auxiliary class Pyridine,Nitrile,Hydrazine,Amine,Hydrazide,Amide, name is 2-Cyanoisonicotinohydrazide, and the molecular formula is C7H6N4O, HPLC of Formula: 135048-32-7.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Cheng, Qiuli published the artcileAntifouling and Antibacterial Polymer-Coated Surfaces Based on the Combined Effect of Zwitterions and the Natural Borneol, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is ACS Applied Materials & Interfaces (2021), 13(7), 9006-9014, database is CAplus and MEDLINE.

The development and application of natural antibacterial materials have always been the focus of biomedical research. Borneol as a natural antibacterial compound has received extensive attention. However, the hydrophobicity caused by its unique structure limits its application range to a certain extent. In this study, we combine zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) with a complex bicyclic monoterpene structure borneol compound and prepare an excellent antifouling and antibacterial surface via the Schiff-base bond. The prepared coating has excellent hydrophilicity verified by the contact angle (CA), and its polymer layer is confirmed by XPS. The zwitterion MPC and borneol moieties in the copolymer play a coordinating role, relying on super hydration and the special stereochem. structure to prevent protein adsorption and inhibit bacterial adhesion, resp., which are demonstrated by bovine serum albumin (BSA) adsorption and antibacterial activity test. Moreover, the water-soluble borneol derivative as the antibacterial surfaces we designed here was biocompatible toward MRC-5 (lung fibroblasts), as showed by in vitro cytotoxicity assays. Such results indicate the potential application of the as-prepared hydrophilic surfaces in the biomedical materials.

ACS Applied Materials & Interfaces published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Hao, Feiyue published the artcileDirect Aziridination of Nitroalkenes Affording N-Alkyl-C-nitroaziridines and the Subsequent Lewis Acid Mediated Isomerization to β-Nitroenamines, Recommanded Product: (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Organic Letters (2017), 19(19), 5442-5445, database is CAplus and MEDLINE.

A mild and highly diastereoselective one-pot synthesis of trans-N-alkyl-C-nitroaziridines was achieved by treatment of nitroalkenes with aliphatic amines and N-chlorosuccinimide. Treatment of the obtained aziridines with a Lewis acid resulted in a facile ring opening reaction, accompanied by rearrangement and isomerization into functionalized (Z)-β-nitroenamines.

Organic Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Recommanded Product: (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Menzies, Donna J. published the artcileAdhesive Prebiotic Chemistry Inspired Coatings for Bone Contacting Applications, Name: 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is ACS Biomaterials Science & Engineering (2017), 3(5), 793-806, database is CAplus and MEDLINE.

New and improved bone-contacting medical devices are required to provide excellent bioactivity at the biointerface. Here, we have used coatings based on prebiotic chem. inspired polymerization of aminomalonitrile (AMN) in combination with comonomers 3,4-di- and 3,4,5-trihydroxybenzaldehyde (DHBA and THBA). The comonomers were incorporated into the AMN coatings to enhance polymerization kinetics, adhesive properties, metal binding efficacy, and human mesenchymal stem cell (hMSC) response. Incorporation of DHBA and THBA as sep. comonomers enhanced the polymerization kinetics compared to that of AMN polymerization alone, with 30 mol % THBA (30T) resulting in a 6-fold increase in thickness over 24 h. Furthermore, the adhesion of AMN coatings to silicon was enhanced when copolymerized with the HBA monomers, where the interfacial adhesion of the 30T coating was increased 20-fold. The ability of the coatings to incorporate zinc ions was investigated, and XPS anal. demonstrated that incorporating 30T increased the binding efficiency 4-fold compared to that of AMN alone. The attachment, proliferation, and morphol. of human mesenchymal stem cells (hMSC) on these coatings was investigated and reported. Finally, the utility of the coatings as osteogenic support matrixes via the induced osteogenic differentiation of hMSCs is reported. The AMN and 30T coatings resulted in the greatest efficiency of osteogenic differentiation, as measured by intracellular ALP activity and mineralization. Incorporation of zinc had a stimulatory effect on hMSC proliferation with 30T coatings, while enhanced mineralization was observed with the zinc functionalized AMN and 30T coatings. This study highlights the potential of prebiotic chem. inspired coatings in biomedical applications.

ACS Biomaterials Science & Engineering published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Name: 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Johansson, Maria H. published the artcileThe influence of metal coordination on ligand geometry: the structure of 2-(diphenylphosphino)acetophenone and bis(2-(diphenylphosphino)acetophenone)palladium(II) bistriflate, Safety of Tetrakis(acetonitrile)palladium(II) Ditriflate, the publication is Journal of Molecular Structure (2002), 606(1-3), 51-59, database is CAplus.

The structures of 2(diphenylphosphino)acetophenone and bis(2(di-Ph phosphino)acetophenone)palladium(II) bistriflate were determined by x-ray crystallog. The ligand is of interest because its P,O donor set combines the hard and soft properties. In the Pd-complex, which was prepared by treating tetrakisacetonitrile-Pd-bistriflate with 2-(diphenylphosphino)acetophenone in CH₂Cl₂ for 4 h at room temperature, the O-coordination provides a masked coordinative unsaturation The ligand crystallizes in the monoclinic space group P2₁/c with a 11.050(2), b 16.052(3), c 9.7082(19) Å, β 109.58(3)°, Z = 4. The Pd-complex crystallizes in the orthorhombic space group P2₁2₁2₁ with a 11.867(2), b 18.162(4), c 19.603(4) Å, Z = 4. Both structures were solved by direct methods and the refinements resulted in the R-values of 0.059 and 0.043, for the organic compound and the Pd compound, resp. Two bi-dentate ligand binds to Pd(II) in a cis-configuration. At. coordinates are given. The Pd-O distances are 2.060(3) and 2.096(2) A and the Pd-P distances 2.2290(10) and 2.2294(10) A, showing a large trans-influence of the P atoms. Half-normal probability plot analyses indicate that the s.u.’s are largely underestimated in the studied structures. The bond-angles around the P atom and the orientation of the keto-substituted Ph rings as well as the orientation of the keto-groups are highly affected by metal complexation.

Journal of Molecular Structure published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Safety of Tetrakis(acetonitrile)palladium(II) Ditriflate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Périères, Lauren published the artcileHepatitis B in Senegal: A Successful Infant Vaccination Program but Urgent Need to Scale Up Screening and Treatment (ANRS 12356 AmBASS survey)., Safety of Phthalonitrile, the main research area is .

Senegal introduced the infant hepatitis B virus (HBV) vaccination in 2004 and recently committed to eliminating hepatitis B by 2030. Updated epidemiological data are needed to provide information on the progress being made and to develop new interventions. We estimated the prevalence of hepatitis B surface antigen (HBsAg) in children and adults living in rural Senegal and assessed hepatitis B treatment eligibility. A cross-sectional population-based serosurvey of HBsAg was conducted in 2018-2019 in a large sample (n = 3,118) of residents living in the Niakhar area (Fatick region, Senegal). Individuals positive for HBsAg subsequently underwent clinical and biological assessments. Data were weighted for age and sex and calibrated to be representative of the area’s population. Among the 3,118 participants, 206 were HBsAg positive (prevalence, 6.9%; 95% confidence interval [CI], 5.6-8.1). Prevalence varied markedly according to age group in individuals aged 0-4, 5-14, 15-34, and â‰?5 years as follows: 0.0% (95% CI, 0.00-0.01); 1.5% (95% CI, 0.0-2.3); 12.4% (95% CI, 9.1-15.6); and 8.8% (95% CI, 6.1-11.5), respectively. Of those subsequently assessed, 50.9% (95% CI, 41.8-60.0) had active HBV infection; 4 (2.9%; 95% CI, 0.9-9.4) were eligible for hepatitis B treatment. Conclusion: In this first population-based serosurvey targeting children and adults in rural Senegal, HBsAg prevalence was very low in the former, meeting the World Health Organization’s (WHO) < 1% HBsAg 2020 target; however, it was high in young adults (15-34 years old) born before the HBV vaccine was introduced in 2004. To reach national and WHO hepatitis elimination goals, general population testing (particularly for adolescents and young adults), care, and treatment scale-up need to be implemented. Hepatology communications published new progress in MEDLINE about 91-15-6, 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Deora, Girdhar Singh published the artcileSubstituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists, Application In Synthesis of 1885-29-6, the main research area is pyridazinone derivative preparation formyl peptide receptor agonist antiinflammatory structure.

Herein we describe the development of a focused series of functionalized pyridazin-3(2H)-one-based formyl peptide receptor (FPR) agonists that demonstrate high potency and biased agonism. The compounds described demonstrated biased activation of prosurvival signaling, ERK1/2 phosphorylation, through diminution of the detrimental FPR1/2-mediated intracellular calcium (Cai2+) mobilization. Compound 50 showed an EC50 of 0.083 μM for phosphorylation of ERK1/2 and an approx. 20-fold bias away from Cai2+ mobilization at the hFPR1.

Journal of Medicinal Chemistry published new progress about pyridazinone derivative preparation formyl peptide receptor agonist antiinflammatory structure. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shinoda, Yusuke published the artcilePrognostic factors of metastatic myxoid liposarcoma., Recommanded Product: Picolinonitrile, the main research area is Metastasis; Myxoid liposarcoma; Prognostic factor.

BACKGROUND: Myxoid liposarcoma (MLS) has the tendency to metastasize extrapulmonary. Although prognostic factors at the initial diagnosis of MLS have been reported, those at diagnosis of metastasis remain unclear. The purpose of this study was to investigate the prognostic factors for disease-specific survival at the initial diagnosis of metastasis. METHODS: This retrospective observational study was conducted at three cancer centers and two university hospitals in Japan. Of 274 MLS patients pathologically diagnosed between 2001 and 2015, 48 metastatic patients were examined. RESULTS: Lung metastases were detected in nine patients (18.8%) and extrapulmonary metastases in 45 (93.8%). Interval from primary diagnosis to the first metastasis was significantly shorter in patients with lung metastases than without (pâ€?â€?.007). Median disease-specific survival after diagnosis of metastases was 52.5 months in all patients. In multivariable analysis, liver metastasis (hazard ratio (HR), 2.71 [95% confidence interval (CI), 1.00-7.09]) and no evidence of disease (NED) achieved by radical treatment (resection with or without radiation therapy, or radiation therapy â‰?0 Gy) or semi-radical (radiation therapy â‰?0 Gy) treatment were significantly related to survival (HR, 0.36; 95%CI [0.13-0.95]). The number of metastases (odds ratio (OR), 0.44; 95%CI [0.25-0.78]) and abdominal/retroperitoneal metastases (OR, 0.09; 95%CI [0.008-0.95]) were the significant inhibitory factors of achieving NED. CONCLUSIONS: This is the first study to statistically demonstrate the importance of achieving NED with surgical resection or radiation therapy for longer survival in metastatic MLS patients. As number of metastases was a significant factor for achieving NED, early detection of metastases might be important.

BMC cancer published new progress about Metastasis; Myxoid liposarcoma; Prognostic factor. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pietta, Piergiorgio published the artcilePurity assay of ketoprofen by high-performance liquid chromatography, Synthetic Route of 42872-30-0, the main research area is ketoprofen purity HPLC; liquid chromatog ketoprofen.

A HPLC method is suitable for purity assay of ketoprofen (I) [22071-15-4]. A Hibar LiChrocart RP C18 column with pH 2.7 MeCO-H2O (37:63) with 50% H3PO4 as eluent and detection at 254 nm are used. Et 4-hydroxybenzoate was chosen as internal standard Linearity was established by chromatographing standard solutions over the range 10-200 ng. The main impurity was 2-[3-(4-methylbenzoyl)phenyl]propionic acid (II) [107257-20-5] (�.4%), while the content of 3-benzoylphenylacetic acid (III) [22071-22-3] was about 0.05%. 2-(3-Benzoylphenyl)propionitrile  [42872-30-0] was almost absent. The method is specific and reproducible.

Journal of Chromatography published new progress about ketoprofen purity HPLC; liquid chromatog ketoprofen. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Synthetic Route of 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mannucci, C. published the artcileHigh-performance liquid chromatography simultaneous quantitation of ketoprofen and parabens in a commercial gel formulation, Application of 2-(3-Benzoylphenyl)propanenitrile, the main research area is ketoprofen paraben determination gel HPLC; chromatog liquid ketoprofen paraben gel.

A simple and rapid procedure for quantitation of ketoprofen and parabens simultaneously in a com. gel formulation by reversed-phase HPLC was developed. The chromatog. anal. was undertaken on a Hypersil ODS column by using a solvent mixture composed of MeCN-KH2PO4 isocratically with a UV detection at 254 nm. Ketoprofen related impurities and hydrolysis product of parabens are well resolved in these conditions and the method can be applied to quality control anal. of ketoprofen and parabens in gel formulation.

Journal of Liquid Chromatography published new progress about ketoprofen paraben determination gel HPLC; chromatog liquid ketoprofen paraben gel. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Application of 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts