Synthesis of macrobicyclic polyamines by direct macrobicyclization via tripode-tripode coupling was written by Dietrich, Bernard;Hosseini, Mir Wais;Lehn, Jean Marie;Sessions, Richard B.. And the article was included in Helvetica Chimica Acta in 1985.Reference of 7528-78-1 This article mentions the following:
Five macrobicyclic polyamines, e.g., I, were prepared by a coupling reaction involving two tripodal subunits. The key macrobicyclization steps involve condensation of a tris-terminal tosylamine tripodal subunit with a tris-terminal tripodal mesylate. Thus, Michael addition of Me acrylate with N(CH2CH2CH2NHTs)3 (II; Ts = tosyl) gave the triester, which was reduced and mesylated to give N(CH2CH2CH2NTsCH2CH2CH2OMs)3 (III; Ms = mesyl). Tripode III was condensed with tripode II at 95° in DMF in the presence of Cs2CO3 to give the macrobicyclic hexatosylamine in 50% yield. The last was detosylated with PhOH in HBr/AcOH to give I as the HBr salt. In the experiment, the researchers used many compounds, for example, 3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1Reference of 7528-78-1).
3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Reference of 7528-78-1
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts