Lv, Zhiliang published the artcileDesign and synthesis of novel 2′-hydroxy group substituted 2-pyridone derivatives as anticancer agents, Computed Properties of 612-13-5, the publication is European Journal of Medicinal Chemistry (2013), 447-453, database is CAplus and MEDLINE.
The authors have synthesized a series of novel pyridones I [R = Ph, 2-BrC6H4, 4-ClC6H4, etc.] and evaluated their antitumor activities in vitro. The bioassays showed that the majority of the resultant compounds exerted inhibitory effects on six human cancer cell lines to various extents. Compound I [R = 4-ClC6H4] showed the best antitumor activities (IC50 values of A549, HeLa and SW480 cancer cell lines were 0.86±0.17 μM, 0.54±0.23 μM and 0.21±0.13 μM, resp.).
European Journal of Medicinal Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Computed Properties of 612-13-5.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts