Li, Ying published the artcileSynthesis and cytotoxicity of dihydroartemisinin ethers containing cyanoarylmethyl group, COA of Formula: C8H6ClNO, the publication is Bioorganic & Medicinal Chemistry (2003), 11(6), 977-984, database is CAplus and MEDLINE.
A new type of ether of dihydroartemisinin containing cyano and aryl groups was prepared and tested for cytotoxicity to A549, P388, L1210 and HT29 cells using the MTT assay. Compounds 12k and 12l were the most cytotoxic compounds Compound 13, lacking the peroxy group, showed a 1000-fold less potency than 12l. Similarly, the inactive compound 14 indicated that the position of cyano groups was also important. Flow cytometry data showed that the compounds caused an accumulation of P388 cells in the G1-phase of the cell cycle.
Bioorganic & Medicinal Chemistry published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, COA of Formula: C8H6ClNO.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts