Chen, Xuwang published the artcileSynthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors, Application In Synthesis of 612-13-5, the publication is European Journal of Medicinal Chemistry (2012), 60-66, database is CAplus and MEDLINE.
A novel series of piperidine-substituted triazine derivatives I(Y = NHMe, MeO, R = 4-F, 4-NO2, 4-MeO, 4-CN, 3-CN, 2-CN, H) and II(Y = NHMe, MeO, R = 4-NO2, 4-CO2H, 4-OH, H) have been synthesized and evaluated for anti-HIV activities in MT-4 cells. Most compounds displayed extremely promising activity against wild-type HIV-1 with EC50 values in low nanomolar concentration, better than that of Nevirapine, Delavirdine, Zidovudine and Dideoxycitidine, and higher potency towards the resistant mutant strain K103N/Y181C than that of Nevirapine and Delavirdine. Selected compounds were also assayed against reverse transcriptase with lower IC50 values than that of Nevirapine. The structure-activity relationship (SAR) of these novel structural congeners was also discussed.
European Journal of Medicinal Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application In Synthesis of 612-13-5.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts