Chen, Wenmin published the artcileDesign, synthesis and biological evaluation of N2,N4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]thiatriazine derivatives as HIV-1 NNRTIs, Name: 2-(Chloromethyl)benzonitrile, the publication is Bioorganic & Medicinal Chemistry (2013), 21(22), 7091-7100, database is CAplus and MEDLINE.
A series of N2,N4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]thiatriazine derivatives (PTTDs, I, X = H, F, Cl, Br; R = PhCH2, 2-cyanobenzyl, CH2CN, allyl, etc.) was designed and synthesized by a facile route. The biol. assay results showed that the five most potent compounds displayed inhibitory activity against HIV-1 at low micromolar concentrations (EC50 = 5.1-8.9 μM). Structure-activity relationship anal. indicated that N2-(3-halogenated-benzyl) analogs were more potent than N2-(unsubstituted-benzyl) analogs. The N4-substitutions contributed to the antiviral activity in the following order: 2-/3-cyano substituted benzyl > 2-/3-halogenated benzyl > non-substituted benzyl > 4-halogenated benzyl. Docking studies revealed the binding conformation of these compounds and provided critical insights for the further development of PTTD analogs.
Bioorganic & Medicinal Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Name: 2-(Chloromethyl)benzonitrile.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts