Chan, Kelvin S. L. published the artcileLigand-enabled cross-coupling of C(sp3)-H bonds with arylboron reagents via Pd(II)/Pd(0) catalysis, Safety of Tetrakis(acetonitrile)palladium(II) Ditriflate, the publication is Nature Chemistry (2014), 6(2), 146-150, database is CAplus and MEDLINE.
There have been numerous developments in C-H activation reactions in the past decade. Attracted by the ability to functionalize mols. directly at ostensibly unreactive C-H bonds, chemists have discovered reaction conditions that enable reactions of C(sp2)-H and C(sp3)-H bonds with a variety of coupling partners. Despite these advances, the development of suitable ligands that enable catalytic C(sp3)-H bond functionalization remains a significant challenge. Herein we report the discovery of a mono-N-protected amino acid ligand that enables Pd(II)-catalyzed coupling of γ-C(sp3)-H bonds in triflyl-protected amines with arylboron reagents. Remarkably, no background reaction was observed in the absence of ligand. A variety of amine substrates and arylboron reagents were cross-coupled using this method. Arylation of optically active substrates derived from amino acids also provides a potential route for preparing non-proteinogenic amino acids.
Nature Chemistry published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Safety of Tetrakis(acetonitrile)palladium(II) Ditriflate.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts