Cai, Pin-Wen published the artcileThe Attractive Application of Lactol Chemistry: From Racemic Lactol to Natural Product Skeleton, Related Products of nitriles-buliding-blocks, the publication is Synthesis (2016), 48(16), 2581-2594, database is CAplus.
A versatile methodol. involving the use of substituted racemic lactols as nucleophiles in the enamine-based asym. reactions leading to functionalized lactones with multiple stereogenic centers as one single diastereoisomer is reported. Importantly, the desired products could be easily transformed into asym. 2,4,5-trisubstituted piperidine derivatives (e.g. I), which are present in numerous alkaloid products but difficult to prepare optically enriched. Moreover, although starting from racemic precursors, the stereoisomeric products were discretely provided by simple column chromatog., which could meet the requirements of atom economy and efficiency.
Synthesis published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Related Products of nitriles-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts