Szekely, Thomas published the artcileDesign, Synthesis, and Immunological Evaluation of a Multicomponent Construct Based on a Glycotripeptoid Core Comprising B and T Cell Epitopes and a Toll-like Receptor 7 Agonist That Elicits Potent Immune Responses, Application of 4-((2,6-Dichloro-9H-purin-9-yl)methyl)benzonitrile, the publication is Journal of Medicinal Chemistry (2018), 61(21), 9568-9582, database is CAplus and MEDLINE.
We present here for the first time the synthesis and immunol. evaluation of a fully synthetic three-component anticancer vaccine candidate, that consists of a β-glycotripeptoid core mimicking a cluster of Tn at the surface of tumor cells (B epitope) conjugated to the OVA 323-339 peptide (T-cell epitope) and a Toll-like receptor 7 (TLR7) agonist for potent adjuvanticity. The immunol. evaluation of this construct and of precursor components demonstrated the synergistic activity of the components within the conjugate to stimulate innate and adaptive immune cells (DCs, T-helper and B-cells). Surprisingly, immunization of mice with the tricomponent GalNAc-based construct elicited low level of anti-Tn IgG but instead elicited very high level of antibodies that recognize the TLR7 agonist. This finding could represent a potential vaccine therapeutic approach for the treatment of some autoimmune diseases such as lupus.
Journal of Medicinal Chemistry published new progress about 115204-76-7. 115204-76-7 belongs to nitriles-buliding-blocks, auxiliary class 5.6_Aromatics,Purines, name is 4-((2,6-Dichloro-9H-purin-9-yl)methyl)benzonitrile, and the molecular formula is C12H25Br, Application of 4-((2,6-Dichloro-9H-purin-9-yl)methyl)benzonitrile.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts