Razafindrainibe, Franck published the artcileSonogashira Cross-Coupling Reaction of Bromocyanofluoro Pyridine Compounds: Access to 5- and 6-Alkynylfluoropyridinamidoximes Scaffolds, Quality Control of 1256788-71-2, the publication is European Journal of Organic Chemistry (2021), 2021(30), 4393-4397, database is CAplus.
A general two-step procedure to access hitherto unknown and under explored 5- and 6-alkynyl-3-fluoro-2-pyridinamidoximes I [R = 4-EtC6H4, 3-pyridyl, tridecyl, etc.; R1 = (N’-hydroxycarbamimidoyl)] from 5- and 6-bromo-3-fluoro-2-cyanopyridines and a wide range of easily available and bench-stable terminal alkynes, using Sonogashira cross-coupling, as the first step was disclosed. The generation of the polar amidoxime group was realized at a late stage upon treatment of the alkynylfluorocyanopyridine I [R = 4-EtC6H4, 3-pyridyl, tridecyl, etc.; R1 = CN] by hydroxylamine. This mild and operationally simple two-step room temperature process was compatible with enantiopure chiral substrates and various functionality including free alcs., unprotected and CBz-protected amines, acetonides, benzyl ethers, amide, imide, di-substituted alkynes and strained saturated heterocycles.
European Journal of Organic Chemistry published new progress about 1256788-71-2. 1256788-71-2 belongs to nitriles-buliding-blocks, auxiliary class Pyridine,Fluoride,Nitrile,Bromide, name is 6-Bromo-3-fluoropicolinonitrile, and the molecular formula is C6H2BrFN2, Quality Control of 1256788-71-2.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts