Gull, Yasmeen published the artcileSynthesis of N-(6-arylbenzo[d]thiazole-2-acetamide) derivatives and their biological activities: an experimental and computational approach, Related Products of nitriles-buliding-blocks, the publication is Molecules (2016), 21(3), 66/1-66/17, database is CAplus and MEDLINE.
Synthesis of N-(6-arylbenzo[d]thiazol-2-yl)acetamides I [Ar = Ph, 4-MeC6H4, 3-Cl-4-FC6H3, etc.] by C-C coupling methodol. in the presence of Pd(0) using various aryl boronic pinacol ester/acids was reported. The newly synthesized compounds I were evaluated for various biol. activities like antioxidant, hemolytic, antibacterial and urease inhibition. In bioassays these I compounds were found to have moderate to good activities. Among the tested biol. activities screened these I compounds displayed the most significant activity for urease inhibition. In urease inhibition, all compounds were found more active than the standard used. The compound I [Ar = Ph, 4-MeC6H4] was found to be the most active. To understand this urease inhibition, mol. docking studies were performed. The in silico studies showed that these acetamide derivatives bind to the non-metallic active site of the urease enzyme. Structure-activity studies revealed that H-bonding of compounds with the enzyme was important for its inhibition.
Molecules published new progress about 479411-95-5. 479411-95-5 belongs to nitriles-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Nitrile,Boronic acid and ester,Benzene,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzonitrile, and the molecular formula is C14H15BF3NO2, Related Products of nitriles-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts