Bischoff, Francois P.’s team published research in Bioorganic & Medicinal Chemistry Letters in 29 | CAS: 13312-84-0

Bioorganic & Medicinal Chemistry Letters published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Application In Synthesis of 13312-84-0.

Bischoff, Francois P. published the artcileDesign and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators, Application In Synthesis of 13312-84-0, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(14), 1737-1745, database is CAplus and MEDLINE.

The discovery, design and synthesis of a new series of GSMs is described. The classical imidazole heterocycle has been replaced by a cyano group attached to an indole nucleus. The exploration of this series has led to compound 26-S (I) which combined high in vitro and in vivo potency with an acceptable drug-like profile.

Bioorganic & Medicinal Chemistry Letters published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Application In Synthesis of 13312-84-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts