Wang, Xueqiang published the artcileMetal-Free Etherification of Aryl Methyl Ether Derivatives by C-OMe Bond Cleavage, HPLC of Formula: 261951-87-5, the publication is Organic Letters (2018), 20(14), 4267-4272, database is CAplus and MEDLINE.
Alkoxyaryl (particularly methoxyaryl) nitriles such as 2-methoxybenzonitrile underwent chemoselective etherification (nucleophilic aromatic substitution) reactions with alcs. mediated by KOt-Bu or KHMDS in 1,4-dioxane to yield different alkoxyaryl nitriles. Primary, secondary, and tertiary alcs. were effective, and natural product or pharmaceutical-derived alcs. were used; the method was used to prepare butoxycaine in three steps from 4-methoxybenzonitrile. 4-Cyanophenyl (+)-menthyl ether was converted to a variety of derivatives by nitrile functionalization reactions. DFT calculations and exptl. results are consistent with potassium ion-mediated activation of the methoxy group through binding to the nitrile and support an SNAr mechanism for the etherification reaction.
Organic Letters published new progress about 261951-87-5. 261951-87-5 belongs to nitriles-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Nitrile,Benzene,Ether, name is 4-Methoxy-3-(trifluoromethyl)benzonitrile, and the molecular formula is C18H12ClNO, HPLC of Formula: 261951-87-5.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts