Ooi, T. published the artcileZr(OBut)4 as an effective promoter for the Meerwein-Ponndorf-Verley alkynylation and cyanation of aldehydes: development of a new asymmetric cyanohydrin synthesis, COA of Formula: C8H6ClNO, the publication is Tetrahedron (2001), 57(5), 867-873, database is CAplus.
Zr(OBut)4 can serve as an effective promoter for the Meerwein-Ponndorf-Verley alkynylation of aldehydes and also facilitate MPV type cyanide transfer to aldehyde carbonyls with com. available acetone cyanohydrin under mild conditions. Based on this finding, a new procedure for asym. cyanohydrin synthesis has been developed employing (4R,5R)-2,2-dimethyl-α,α,α’,α’-tetraphenyl-1,3-dioxolane-4,5-dimethanol (TADDOL, I) as a chiral ligand. For instance, sequential treatment of a CH2Cl2 solution of I (1 equiv) with Zr(OBut)4 (1 equiv) and acetone cyanohydrin (2 equiv) at room temperature for 1 h, and subsequent reaction with 3-phenylpropanal at -40° for 7.5 h resulted in formation of the corresponding cyanohydrin in 63% isolated yield with 85% ee. The scope and limitations of this method have been clarified with various aldehydes as substrates.
Tetrahedron published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, COA of Formula: C8H6ClNO.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts