Kelley, James L. published the artcile9-Benzyl-6-(dimethylamino)-9H-purines with antirhinovirus activity, Related Products of nitriles-buliding-blocks, the publication is Journal of Medicinal Chemistry (1988), 31(10), 2001-4, database is CAplus and MEDLINE.
A series of 9-benzyl-6-(dimethylamino)-9H-purines and 9-benzyl-2-chloro-6-(dimethylamino)-9H-purines were synthesized and tested in cell culture for activity against rhinovirus type 1B. The 9-benzylpurines that were unsubstituted in the 2-position had weak activity. However, introduction of a 2-chloro substituent resulted in a substantial increase in antiviral activity. One of the most active compounds, 2-chloro-6-(dimethylamino)-9-(4-methylbenzyl)-9H-purine (I, R = Me), had an IC50 value of 0.08 μM against serotype 1B. I (R = Cl, Me, Et, Me2CH) were tested against 18 other rhinovirus serotypes, but the majority tested were less sensitive than type 1B. The range of serotype sensitivity for I (R = Me) varied from 0.08 to 14 μM. These 9-benzyl-2-chloro-9H-purines represent a new class of antiviral agents with in vitro activity against rhinoviruses.
Journal of Medicinal Chemistry published new progress about 115204-76-7. 115204-76-7 belongs to nitriles-buliding-blocks, auxiliary class 5.6_Aromatics,Purines, name is 4-((2,6-Dichloro-9H-purin-9-yl)methyl)benzonitrile, and the molecular formula is C13H7Cl2N5, Related Products of nitriles-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
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