Griffiths, M. H. published the artcileThe comparative metabolism of 2,6-dichlorothiobenzamide (Preflx) and 2,6-dichlorobenzonitrile in the dog and rat, Related Products of nitriles-buliding-blocks, the publication is Biochemical Journal (1966), 98(3), 770-81, database is CAplus and MEDLINE.
A single oral dose of either 2,6-dichlorothiobenzamide-14C (I) or 2,6-dichlorobenzonitrile-14C (II) fed to rats is almost entirely eliminated in 4 days; 84.8-100.5% of 14C from I is excreted 67.3-79.7% in the urine; 85.8-97.2% of 14C from II is excreted, 72.3-80.7% in the urine. Only 0.37% of the I dose and 0.25 ± 0.03% of the II dose are present in the carcass plus viscera after gut removal. Rats do not show sex differences in the pattern of elimination of the resp. metabolites of the two herbicides. The rates of elimination of 14C from the two compounds in the 24-hr. and 48-hr. urines are not different from one another. After oral administration to dogs, 85.9-106.1% of 14C from I is excreted, 66.6-80.9% in the urine, and 86.8-92.5% of 14C from II is excreted, 60.0-70.1% in the urine. Dogs do not show sex differences in the pattern of eliminating the metabolites of either I or II. Dogs and rats do not show species differences in the patterns of elimination of the two herbicides. I and II are completely metabolized; unchanged I and II are absent from the urine and feces, and from the carcasses when elimination is complete. In the hydrolyzed urine of rats dosed with either I or II, 2,6-dichloro-3-hydroxybenzonitrile accounts for approx. 42% of the 14C, a further 10-11% is accounted for by 2,6-dichlorobenzamide, 2,6-dichlorobenzoic acid, 2,6-dichloro-3- and -4-hydroxybenzoic acid and 2,6-dichloro-4-hydroxybenzonitrile collectively, and 25-30% by six polar constituents, of which two are S-containing amino acids. In the unhydrolyzed urines of rats dosed with either I or II, there are present free 2,6-dichloro-3- and -4-hydroxybenzonitrile, their glucuronide conjugates, ester glucuronides of the principal aromatic acids that are present in the hydrolyzed urines, and two S-containing metabolites analogous to mercapturic acids or premercapturic acids.
Biochemical Journal published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, Related Products of nitriles-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts