Zhou, Zhong’s team published research in ChemistrySelect in 2021-03-15 | CAS: 100-70-9

ChemistrySelect published new progress about Alkylation. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Zhou, Zhong published the artcileSilver-Catalyzed Cross Dehydrogenative Coupling between Heteroarenes and Cyclic Ethers under Mild Conditions, COA of Formula: C6H4N2, the main research area is hereroaryl cyclic ether preparation; heteroarene cyclic ether cross dehydrogenative coupling silver catalyst.

A new strategy for the straightforward alkylation of heteroarenes (such as 2-phenylpyridine, 2-methylquinoline, 6-bromo-isoquinoline, etc.) under mild conditions was developed. Silver catalyst was employed for the cross dehydrogenative coupling between heteroarenes and cyclic ethers (such as THF, tetrahydropyran, [1,4]dioxane, [1,3]dioxolane) to construct a new C(sp2)-C(sp3) bond. This reaction was carried out in water under room temperature and applicable to various heteroarenes such as pyridines, quinolines and isoquinolines derivatives with good functional group compatibility.

ChemistrySelect published new progress about Alkylation. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts