Meng, Xiang-He published the artcileNaN(SiMe3)2/CsTFA Copromoted Aminobenzylation/Cyclization of 2-Isocyanobenzaldehydes with Toluene Derivatives or Benzyl Compounds: One-Pot Access to Dihydroquinazolines and Quinazolines, Recommanded Product: 2-Formyl-4,5-dimethoxybenzonitrile, the main research area is dihydroquinazoline chemoselective preparation; isocyanobenzaldehyde toluene derivative aminobenzylation cyclization sodium bistrimethylsilylamide cesium trifluoroacetate; quinazoline chemoselective preparation; benzylbenzotriazole isocyanobenzaldehyde aminobenzylation cyclization sodium bistrimethylsilylamide cesium trifluoroacetate.
A NaN(SiMe3)2/CsTFA copromoted aminobenzylation/cyclization reaction of 2-isocyanobenzaldehydes with toluene derivatives or benzyl compounds to afford 4-benzylsubstitued dihydroquinazolines I [R1 = H, Me, OPh, etc.; Ar = Ph, 1-naphthyl, 4-NMe2, etc.] and quinazoline derivatives II [Ar1 = Ph, 4-MeOC6H4, 2-naphthyl] were developed. Further applications, including synthesis of quinazoline, dihydroindolo[1,2-c]quinazoline and dihydro-8H-isoquinolino[2,3-c]quinazoline, demonstrated the tremendous potential of the tandem reaction.
Journal of Organic Chemistry published new progress about Alkyl groups. 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Recommanded Product: 2-Formyl-4,5-dimethoxybenzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts