Xiao, Yuanyuan published the artcileEnantioselective Construction of Spiro Thiazol-4-one Derivatives with Multiple Stereocenters via an Organocatalyzed Multicomponent Cascade Reaction, Computed Properties of 5153-73-1, the publication is Advanced Synthesis & Catalysis (2018), 360(10), 1961-1966, database is CAplus.
An organocatalyzed asym. three-component reaction of thiazol-4-ones, acrolein and nitroolefins, which provides an efficient approach to access optically active spiro thiazol-4-ones I (R = C6H5, 4-FC6H4, 4-F3CC6H4, etc.; R1 = C6H5, 1-naphthyl, 2-thienyl, etc.) is developed. Under the catalysis of a bifunctional squaramide derived from L-tert-leucine, the reactions of a wide range of thiazol-4-ones, acrolein and nitroolefins took place smoothly to generate the corresponding spirothiazolone derivatives bearing four contiguous stereogenic centers in good yields with high levels of enantioselectivity. The title chiral spirothiazolones were obtained as a pair of separable epimers, which are formed through a double Michael addition followed by a Henry process.
Advanced Synthesis & Catalysis published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C4H3Cl2N3, Computed Properties of 5153-73-1.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts