Wan, Jinlin published the artcileDesign, synthesis and anti-bacterial evaluation of novel 1,3,4-thiadiazole derivatives bearing a semicarbazone moiety, Application In Synthesis of 612-13-5, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2018), 193(7), 443-450, database is CAplus.
(Alkylthio)thiadiazolyl semicarbazones of 2-chloro-3-indolecarboxaldehyde I (R = R1CH2, Me, Et, n-Pr, Bu, BuCH2; R1 = Ph, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 2-FC6H4, 4-FC6H4, 2-NCC6H4, 2,4-Cl2C6H3) were prepared as agrochem. antibacterial agents for treatment of rice bacterial leaf blight (Xanthomonas oryzae pv. oryzae, Xoo) and citrus canker (Xanthomonas axonopodis pv. citri, Xac). I were prepared in four steps from 5-amino-1,3,4-thiadiazole-2-thiol, benzyl chlorides or alkyl bromides, and 2-chloro-3-indolecarboxaldehyde (prepared in one step from oxindole). Many of the tested compounds exhibited excellent activity (≥74.19%) against Xoo at a concentration of 200 μg/mL, with 50% effective concentration (EC50) values ranging from 12.21 to 67.20 μg/mL, superior to the com. antibacterial agent bismerthiazol (EC50 = 92.23 μg/mL). I (R = 2-ClC6H4CH2) demonstrated good inhibitory activity against Xac (89.46% at 200 μg/mL) and Xoo (EC50 = 18.28 μg/mL), while I (R = 4-MeOC6H4CH2) displayed excellent activity against Xoo with an EC50 value of 12.21 μg/mL.
Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 612-13-5.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts