Natte, Kishore published the artcilePalladium-Catalyzed Trifluoromethylation of (Hetero)Arenes with CF3Br, Formula: C9H6F3NO, the publication is Angewandte Chemie, International Edition (2016), 55(8), 2782-2786, database is CAplus and MEDLINE.
The CF3 group is an omnipresent motif found in many pharmaceuticals, agrochems., catalysts, materials, and industrial chems. Despite well-established trifluoromethylation methodologies, the straightforward and selective introduction of such groups into (hetero)arenes using available and less expensive sources is still a major challenge. In this regard, the selective synthesis of various trifluoromethyl-substituted (hetero)arenes by palladium-catalyzed C-H functionalization is herein reported. This novel methodol. proceeds under comparably mild reaction conditions with good regio- and chemoselectivity. As examples, trifluoromethylations of biol. important mols., such as melatonin, theophylline, caffeine, and pentoxifylline, are showcased.
Angewandte Chemie, International Edition published new progress about 261951-87-5. 261951-87-5 belongs to nitriles-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Nitrile,Benzene,Ether, name is 4-Methoxy-3-(trifluoromethyl)benzonitrile, and the molecular formula is C9H6F3NO, Formula: C9H6F3NO.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts