Liu, Tao published the artcileDesign, Synthesis, and Biological Evaluation of Novel 4-Aminopiperidinyl-linked 3,5-Disubstituted-1,2,6-thiadiazine-1,1-dione Derivatives as HIV-1 NNRTIs, Safety of 2-(Chloromethyl)benzonitrile, the publication is Chemical Biology & Drug Design (2015), 86(1), 887-893, database is CAplus and MEDLINE.
A novel series of 4-aminopiperidinyl-linked 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives I [R = 3-CN, 4-NO2, 2,4,6-(CH3)3, etc.; Ar = 1-naphthyl, 2,4-dichlorophenyl] were designed, synthesized, and evaluated for their in vitro anti-HIV activities in MT-4 cells based on the hybridization of the privileged fragments in DABO and DAPY-typed HIV-1 NNRTIs. Most of the target compounds showed weak inhibitory activity against WT HIV-1. In order to confirm the mode of action of the target compounds, representative compounds I (R = 4-NO2; Ar = 1-naphthyl) and I (R = 4-NO2; Ar = 2,4-dichlorophenyl) were selected to perform the HIV-1 RT inhibitory assay. In this assay, I (R = 4-NO2; Ar = 1-naphthyl) and I (R = 4-NO2; Ar = 2,4-dichlorophenyl) displayed good activity with IC50 values of 3.15 and 1.52 μM, resp. Addnl., preliminary structure-activity relationships (SARs) anal. and mol. docking studies of newly synthesized compounds were also discussed.
Chemical Biology & Drug Design published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Safety of 2-(Chloromethyl)benzonitrile.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts