Li, Hui published the artcileSynthesis and evaluation of the anticonvulsant activity of 9-alkyl-2,9-dihydro-3H-1,2,4-triazolo[4,3-a]benzimidazole-3-one derivatives, Category: nitriles-buliding-blocks, the publication is Latin American Journal of Pharmacy (2015), 34(1), 5-12, database is CAplus.
A series of novel benzimidazole derivatives I [R = Pr, Bu, benzyl, etc.] were synthesized via reaction of 2-chloro-N-substituted-benzimidazole II with Me hydrazinocarboxylate. The synthesized compounds were screened for their in vivo anticonvulsant activity and neurotoxicity(NT) by maximal electroshock test(MES) and rotarod test. Among the synthesized compounds, I [R = 2,6-Cl2C6H3CH2] was the most active compound with a median ED (ED50) of 31.69 mg/kg, a median toxicity dose (TD50) > 350 mg/kg, and the protective index (PI) > 11.04 by i.p. administration in the mice. Meanwhile, compound I [R = 2,6-Cl2C6H3CH2] exhibited ED50 values of 44.01 mg/kg and the PI values of 31.6 by oral administration.
Latin American Journal of Pharmacy published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Category: nitriles-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts