Lei, Zhen-lin published the artcileSynthesis and antifungal activities of 7-ether coumarin derivatives, Application In Synthesis of 612-13-5, the publication is Huaxue Shiji (2016), 38(2), 157-162, database is CAplus.
7-Hydroxy 4,6-dimethyl-coumarin and 7-hydroxy-4,8-dimethyl-coumarin were synthesized by Peachmann condensation reaction, and then reacted with a substituted benzyl chloride to yield twenty-three new coumarin compounds The structures of all compounds were confirmed by 1HNMR and LC-MS spectrometry. The preliminary bioassay indicated that compound 7-(4-fluoro-benzyloxy)-4,6-dimethyl-2H-benzopyran-2-one (3c), 4,6-dimethyl-7-(2-methyl-benzyloxy)-2H-pyran-2-one (3j), 7-(4-methoxy-benzyloxy)-4,6-dimethyl-2H-pyran-2-one (3k), 7-(4-fluoro-benzyloxy)-4,8-dimethyl-2H-pyran-2-one (3n) and 7-(4-methoxy-benzyloxy)-4,8-dimethyl-2H-pyran-2-one (3w) showed over 70% antifungal activities against Botryodiplodia theobromae at 100 mg/L, and compound 7-(3-chloro-benzyloxy)-4,8-dimethyl-2H-pyran-2-one (3p) showed broad-spectrum antifungal activity.
Huaxue Shiji published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application In Synthesis of 612-13-5.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts