Zhang, Wenjun published the artcilePalladium-catalyzed Aminocarbonylation of Benzylic Chlorides Using Carbamoylsilane as an Amide Source: Efficient Access of Secondary Aryl Acetamides, Formula: C8H6ClN, the publication is Current Organic Synthesis (2017), 14(7), 1067-1072, database is CAplus.
A novel and highly efficient synthetic method toward secondary arylacetamides RCH2C(O)N(CH3)CH2OCH3 (R = Ph, 3,4-Cl2C6H3, C6H5CH=CH, naphth-1-yl, etc.) by palladium-catalyzed aminocarbonylation of aryl halides RCH2Cl was developed using N-methoxymethyl-N-methylcarbamoyl(trimethyl)silane as amide source. The methoxymethyl group was used as an amino protecting group and can be easily hydrolyzed in acid condition to afford secondary arylacetamides RCH2C(O)NHCH3 . The scope and limitation of the aminocarbonylation were investigated. The relative position of substituent on the aryl ring is used to influence on this transformation. In this protocol, the methoxymethyl group was used as an amino protecting group and can be easily hydrolyzed.
Current Organic Synthesis published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C10H12O5, Formula: C8H6ClN.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts