Yosef, Hisham Abdallah A. published the artcileSynthesis and biological evaluation of some novel chiral carbamates and 4-imino-2- oxazolidinones derived from selected optically active cyanohydrins, Application of 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, the publication is Pharma Chemica (2017), 9(16), 6-21, database is CAplus.
The reaction of tert-Bu isocyanate with the optically active cyanohydrins was accompanied with inversion of configuration giving the chiral (S)-enantiomers of the resp. carbamate derivatives On the other hand, reactions of aryl isocyanate reagents Ar-N=C=O with cyanohydrins gave the corresponding optically active 4-imino-2-oxazolidinone derivatives in the form of their S-configuration. Moreover, the same reactions were also applied for the racemic cyanohydrins to afford the corresponding carbamates and/or 4-imino-2-oxazolidinones as racemic mixtures Structures of the new products were elucidated with compatible micro anal. and spectroscopic (IR, 1H-NMR, 13C-NMR and MS) measurements. The X-ray crystallog. anal. provided an efficient tool in confirming the structure and configuration of the new chiral compounds The antimicrobial activity of selected new derivatives against four bacterial species (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa) and two fungi (Aspergillus flavus and Candida albicans) were evaluated. Moreover, some of the new products were screened for their in-vitro antitumor activity against the human solid cancer cell lines, human carcinoma (HCT116), human hepatocellular liver carcinoma (HepG2) and human breast adenocarcinoma (MCF-7) cell lines. Generally, most of the investigated compounds were showed moderate to high activities in comparison with the standard drugs. The structure-activity relationship (SAR) was also discussed.
Pharma Chemica published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C2H5BF3K, Application of 2-(2-Chlorophenyl)-2-hydroxyacetonitrile.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts