Wang, Shi-Ben published the artcileSynthesis and evaluation of anticonvulsant and antidepressant activities of 7-alkyl-7H-tetrazolo[1,5-g]purine derivatives, Application In Synthesis of 612-13-5, the publication is Medicinal Chemistry Research (2014), 23(10), 4619-4626, database is CAplus.
7-Alkyl-7H-tetrazolo[1,5-g]purines were synthesized, and their anticonvulsant and antidepressant activities were evaluated in a mouse model. The anticonvulsant effect and neurotoxicity of the compounds were evaluated with a maximal electroshock test and a rotated test in mice, resp. Most of the compounds had anticonvulsant activity. Among the compounds studied, 7-(3-chlorobenzyl)-7H-tetrazolo[1,5-g]purine (I) was the most potent compound with a median ED (ED50) of 28.9 mg/kg and a protective index of 15.8, possessing better anticonvulsant activity and higher safety than carbamazepine. To explain the possible mechanism of anticonvulsant activity, I was tested in pentylenetetrazole-induced seizures, and the results suggest that I exerts anticonvulsant activity through a GABA-mediated mechanism. Forced swimming test showed that at 40 mg/kg, some of the compounds have significant antidepressant activity, the most active compound being 7-(2-chlorobenzyl)-7H-tetrazolo[1,5-g]purine decreasing immobility time by 56%.
Medicinal Chemistry Research published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H7NO4, Application In Synthesis of 612-13-5.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts