Stuckey, Jacob I. published the artcileIdentification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity, Product Details of C8H8N2OS, the publication is Journal of Biological Chemistry (2021), 100349, database is CAplus and MEDLINE.
Kinetic methodologies for studying EZH2-inhibitor-binding kinetics that had allowed to identify a unique structural modification that results in significant increases in the drug-target residence times of all EZH2 inhibitor scaffolds was studied. The unexpected residence time enhancement bestowed by this modification had enabled us to create a series of second-generation EZH2 inhibitors with sub-pM binding affinities. Both biophys. evidence validating this sub-pM potency and biol. evidence demonstrating the utility and relevance of such high-affinity interactions with EZH2 was provided.
Journal of Biological Chemistry published new progress about 57663-05-5. 57663-05-5 belongs to nitriles-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Tetrahydropyrimidins, name is 6-Methyl-4-(methylthio)-2-oxo-1,2-dihydropyridine-3-carbonitrile, and the molecular formula is C12H10F2Si, Product Details of C8H8N2OS.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts