Lin, Kuaile published the artcileSynthesis and biological evaluation of xanthine derivatives on dipeptidyl peptidase 4, Formula: C8H6ClN, the publication is Chemical & Pharmaceutical Bulletin (2013), 61(4), 477-482, database is CAplus and MEDLINE.
A series of xanthine derivatives in which a methylene was inserted at position eight of xanthine scaffold was synthesized and evaluated as inhibitors of dipeptidyl peptidase 4 (DPP-4) for the treatment of type 2 diabetes. As a results of a structure-activity relationship (SAR) study of the series, the compounds with 4-methyl-quinazoline-2-yl-Me group at N-1 position and 2-aminoethylaminomethyl group displayed better antidiabetic activity. Two compounds inhibited DPP-4 and displayed a more than 100-fold selectivity over DPP-7 and DPP-8. The title compounds thus formed included a xanthine derivative (I) and related substances, such as 8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione (linagliptin) and analogs, such as 2,2′-[[8-[(3R)-3-amino-1-piperidinyl]-3,6-dihydro-3-methyl-2,6-dioxo-1H-purine-1,7(2H)-diyl]bis(methylene)]bis[benzonitrile]. The synthesis of the target compounds was achieved using 3,9-dihydro-8-(hydroxymethyl)-3-methyl-1H-purine-2,6-dione as a key intermediate.
Chemical & Pharmaceutical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Formula: C8H6ClN.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts