Li, Zhenyu published the artcileSynthesis and anti-HIV evaluation of novel 1,2,4-triazole derivatives as potential non-nucleoside HIV-1 reverse transcriptase inhibitors, Name: 2-(Chloromethyl)benzonitrile, the publication is Letters in Drug Design & Discovery (2013), 10(1), 27-34, database is CAplus.
A series of novel 1,2,4-triazole derivatives was designed and synthesized. All of the new compounds were evaluated for their anti-HIV activities in MT-4 cells. Three of them showed moderate activities against wild-type HIV-1 with an EC50 of 17.4-4.87 μM. Among the active compounds, 3-{[4-(3,4-dimethoxybenzylidenamino)-5-(furan-2-yl)-4H-1,2,4-triazol-3-ylthio]methyl}benzonitrile was identified as the promising compound (EC50 = 17.4 μM, SI = 13). However, no compound displayed inhibitory activity against HIV-2.
Letters in Drug Design & Discovery published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Name: 2-(Chloromethyl)benzonitrile.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts