Khomenko, Dmytro M. published the artcileSynthesis of α-substituted 2-(1H-1,2,4-triazol-3-yl)acetates and 5-amino-2,4-dihydro-3H-pyrazol-3-ones via the Pinner strategy, Application In Synthesis of 30431-99-3, the publication is Tetrahedron Letters (2021), 152956, database is CAplus and MEDLINE.
A series of 2-(1H-1,2,4-triazol-3-yl)acetates, as well as 4-mono- and 4,4-disubstituted 5-amino-2,4-dihydro-3H-pyrazol-3-ones (including spirocyclic derivatives) I [R1 = H, i-Pr, Me; R2 = H, Me; R1R2 = -(CH2)2-, -(CH2)3-, -(CH2)2O(CH2)2-] have been synthesized using the Pinner reaction strategy. α-Mono- and α,α-disubstituted Et cyanoacetates NCC(R1)(R2)C(O)OEt were converted into the corresponding carboxyimidate salts EtOC(=NH)C(R1)(R2)C(O)OEt.HCl that served as the key intermediates. Their further reaction with formylhydrazide or hydrazine hydrate provided triazolylacetates I or aminopyrazolones (including spirocyclic derivatives) II, depending on the structure of the starting Pinner salt and the nature of the nucleophile. The scope and limitations of the developed synthetic method have been established.
Tetrahedron Letters published new progress about 30431-99-3. 30431-99-3 belongs to nitriles-buliding-blocks, auxiliary class Tetrahydropyran,Nitrile,Ester, name is Ethyl 4-cyanotetrahydro-2H-pyran-4-carboxylate, and the molecular formula is C9H13NO3, Application In Synthesis of 30431-99-3.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts