Izquierdo, Joseba published the artcileEnantioselective Synthesis of 5,5-Disubstituted Hydantoins by Bronsted Base/H-Bond Catalyst Assisted Michael Reactions of a Design Template, Safety of (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Chemistry – A European Journal (2018), 24(28), 7217-7227, database is CAplus and MEDLINE.
A new method for the enantioselective synthesis of 5,5-disubstituted (quaternary) hydantoins, e.g., I was developed on the basis of an organocatalytic Michael reaction approach involving the use of 2-benzylthio-3,5-dihydroimidazol-4-ones as key hydantoin surrogates. The method is general with respect to the substitution pattern at the hydantoin N1 (alkyl, aryl, acyl), N3 (aryl), and C5 (linear/branched alkyl, aryl) positions and affords essentially single diastereomeric products with enantioselectivities higher than 95 % ee in most cases. Among the bifunctional Bronsted base/H-bond catalysts examined, a known squaramide-tertiary amine catalyst II and a newly prepared squaramide-tertiary amine catalyst III provide the highest selectivity so far with either nitroolefins or vinyl ketones as the acceptor components. Kinetic measurements support a first-order rate dependence on both reaction partners, the donor template and the Michael acceptor, whereas competitive 1H NMR spectroscopy experiments reveal the high ability of the template for catalyst binding.
Chemistry – A European Journal published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Safety of (E)-4-(2-Nitrovinyl)benzonitrile.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts