Martin, Rainer E. published the artcileSynthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2), Recommanded Product: 4-(5-Oxazolyl)benzonitrile, the main research area is cyclopentapyridine cyclohexapyridine preparation SAR aldosterone synthase inhibitory; continuous flow Kondrateva reaction.
A series of cyclopenta[c]pyridine aldosterone synthase (AS) inhibitors were conveniently accessed using batch or continuous flow Kondrat’eva reactions. Preparation of the analogous cyclohexa[c]pyridines, e. g., I, led to the identification of a potent and more selective AS inhibitor. The structure-activity-relationship (SAR) in this new series was rationalized using binding mode models in the crystal structure of AS.
Organic & Biomolecular Chemistry published new progress about Flow. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Recommanded Product: 4-(5-Oxazolyl)benzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts