Kanaoka, Yuichi published the artcilePolyphosphate ester as a synthetic agent. XII. Convenient synthesis of nitriles by the dehydration of amides with PPE, Application of 2,3-Dimethoxybenzonitrile, the main research area is polyphosphate ester synthesis benzonitrile; benzonitrile polyphosphate ester synthesis; naphthonitrile polyphosphate ester synthesis; furonitrile polyphosphate ester synthesis; nicotinonitrile polyphosphate ester synthesis; cyano cyclohexane polyphosphate ester synthesis; cyclopentane cyano polyphosphate ester synthesis; nitrile benzo polyphosphate ester synthesis.
Nitriles were prepared in improved yields by the dehydration of amides with PPE, prepared from P2O5 and Et2O. Thus, a solution of BzNH2 and PPE in CHCl3 was refluxed 2 hr to give 87% PhCN. m-Nitrobenzonitrile, p-nitrobenzonitrile, o-chlorobenzonitrile, m-hydroxybenzonitrile, p-hydroxybenzonitrile, m-methoxybenzonitrile, p-methoxybenzonitrile, 2,3-dimethoxybenzonitrile, β-naphthonitrile, cyclopentanecarbonitrile, cyclohexanecarbonitrile, phenylacetonitrile, 2-furonitrile, nicotinonitrile, and isonicoinonitrile, were similarly prepared, but 2-furancarboxamide resisted dehydration. The primary amides were prepared by ammonolysis of the corresponding acid chlorides.
Chemical & Pharmaceutical Bulletin published new progress about Nitriles. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Application of 2,3-Dimethoxybenzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts