Deora, Girdhar Singh published the artcileSubstituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists, Application In Synthesis of 1885-29-6, the main research area is pyridazinone derivative preparation formyl peptide receptor agonist antiinflammatory structure.
Herein we describe the development of a focused series of functionalized pyridazin-3(2H)-one-based formyl peptide receptor (FPR) agonists that demonstrate high potency and biased agonism. The compounds described demonstrated biased activation of prosurvival signaling, ERK1/2 phosphorylation, through diminution of the detrimental FPR1/2-mediated intracellular calcium (Cai2+) mobilization. Compound 50 showed an EC50 of 0.083 μM for phosphorylation of ERK1/2 and an approx. 20-fold bias away from Cai2+ mobilization at the hFPR1.
Journal of Medicinal Chemistry published new progress about pyridazinone derivative preparation formyl peptide receptor agonist antiinflammatory structure. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts