Month: November 2022

Rozhkova, Yuliya S. published the artcileSynthesis of novel racemic 3,4-dihydroferroceno[c]pyridines via the Ritter reaction, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is dihydroferroceno pyridine preparation crystal mol structure; Ritter reaction methyl ferrocenylpropanol nitrile methansulfonic acid.

A new approach for the synthesis of functionalized racemic 3,4-dihydroferroceno[c]pyridines via the Ritter reaction of 2-methyl-1-ferrocenylpropan-1-ol with nitriles in the presence of methansulfonic acid was developed. The scope and limitations of the reaction were evaluated. Selected racemic 3,4-dihydroferroceno[c]pyridines were successfully separated by preparative HPLC on a Chiralcel OD-H column. The absolute configuration of the enantiomers was determined by x-ray crystal structure anal.

Tetrahedron Letters published new progress about Crystal structure. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rozhkova, Yuliya S. published the artcileSynthesis of novel racemic 3,4-dihydroferroceno[c]pyridines via the Ritter reaction, Related Products of nitriles-buliding-blocks, the main research area is dihydroferroceno pyridine preparation crystal mol structure; Ritter reaction methyl ferrocenylpropanol nitrile methansulfonic acid.

A new approach for the synthesis of functionalized racemic 3,4-dihydroferroceno[c]pyridines via the Ritter reaction of 2-methyl-1-ferrocenylpropan-1-ol with nitriles in the presence of methansulfonic acid was developed. The scope and limitations of the reaction were evaluated. Selected racemic 3,4-dihydroferroceno[c]pyridines were successfully separated by preparative HPLC on a Chiralcel OD-H column. The absolute configuration of the enantiomers was determined by x-ray crystal structure anal.

Tetrahedron Letters published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reshma, G. published the artcileSynthesis and structure of mono and bis {1,3-bis(2-pyridylimino)isoindoline} supported 3d transition metal complexes, Synthetic Route of 91-15-6, the main research area is mono bis pyridyliminoisoindoline transition metal complex preparation; crystal mol structure cobalt bis pyridyliminoisoindoline complex; manganese iron cobalt nickel copper zinc pyridyliminoisoindoline complex preparation.

Series of homoleptic and heteroleptic 3d transition metal complexes were prepared in anal. pure form and high yield, by reacting appropriate metal precursors with 1,3-bis(2-pyridylimino)isoindolate (BPIH) ligand under suitable reaction conditions. The complexes were characterized by various spectro-anal. techniques, including IR, UV, NMR, ESI Mass and x-ray crystal anal. A distorted octahedral structure containing two meridionally coordinating BPI ligands was assigned to all the homoleptic complexes. While, for the heteroleptic complexes, a highly distorted square pyramidal geometry, with a planar tridentate BPI ligand coordinating to the metal center along with chloro and aqua ligands was assigned. Considering the unique structural features of the complexes, potential catalytic applications are envisaged.

Journal of Molecular Structure published new progress about Crystal structure. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhan, Yong published the artcileMechanofluorochromism based on BOPIM complexes: The effect of substituents and regulation of the direction of the emission color changes, Related Products of nitriles-buliding-blocks, the main research area is preparation boron pyridyl imidazole complex; crystal mol structure boron pyridyl imidazole complex; mechanofluorochromism boron pyridyl imidazole complex; thermal decomposition boron pyridyl imidazole complex.

Novel boron 2-(2′-pyridyl)imidazole (BOPIM) complexes T1, T2 and T3 with different substituents (including bromo, tert-Bu and methoxyl) on the benzene ring of BOPIM dyes were designed and synthesized, and their optical properties in both solution and the solid state were studied and compared. The three compounds exhibited typical intramol. charge transfer (ICT) characteristics. Solvent-dependent UV-visible absorption, fluorescence emission spectra and quantum chem. calculation indicated a mol. push-pull electronic structure. Their ICT degrees increased with the sequence of T1 < T2 < T3. The anal. of the x-ray crystal structure revealed the twisted mol. conformation of BOPIM dyes. Furthermore, they showed remarkable reversible mechanofluorochromic (MFC) features under mech. force. The MFC activities could be tuned easily by changing the substituents on the BOPIM dyes. T1 exhibited emission color change from bright green to yellowish green with a spectral red shift of only 22 nm under mech. stimuli, whereas T2 and T3 gave the large spectral red shifts of 36 and 30 nm. Electronic and steric effects of the substitutes were proved playing significant roles in regulating the ICT effect and intermol. interactions. More importantly, the remarkable effect of substituents on the MFC behaviors of BOPIM dyes will provide an effective way to obtain novel high-contrast MFC dyes. Dyes and Pigments published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Saha, Sayantani published the artcileCatalytic Recycling of a Th-H Bond via Single or Double Hydroboration of Inactivated Imines or Nitriles, Quality Control of 100-70-9, the main research area is metallacycle thorium amide preparation crystal mol structure catalyst hydroboration; selective dihydroboration nitrile aldimine inactivated imine nitrile hydroboration catalyst.

The catalytic activity of the metallacycle thorium amide [(Me3Si)2N]2Th[κ2-(N,C)-CH2Si(CH3)2N(SiMe3)] (Th1) is presented for the selective dihydroboration of nitriles (-CN) with pinacolborane (HBpin). Using significantly low catalyst loading (0.1 mol %), the dihydroborated amines were achieved by the hydroboration of the -CN triple bond attached with aromatic, aliphatic, and heteroatom backbones with high turnover frequency (TOF) as compared to all the reported homogeneous metal catalysts in this reaction. In addition, for aldimines (-C=N-), the hydroboration precatalyst Th2 has been synthesized by the protonolysis of a seven-membered N-heterocyclic iminato ligand (LH) and Th1. The Th2 crystal structure and its performance in the synthesis of hydroborated secondary amine are also here presented. Detailed kinetic studies and thermodn. and stoichiometric experiments provided us with cumulative evidence supporting the proposed mechanism for the aforementioned reactions.

ACS Catalysis published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qurban, Jihan published the artcileSynthesis, characterization and reactivity of novel pseudocyclic hypervalent iodine reagents with heteroaryl carbonyl substituents, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is heteroaryl hydroxy benzoiodaoxolium triflate preparation crystal structure oxidative reaction.

Two new hypervalent iodine reagents containing furan and thiophene moieties in addition to a carbonyl group in the vicinity of the iodine atom were synthesized and characterized. The X-ray anal. of both compounds revealed a strong intramol. contact between the carbonyl oxygen and the hypervalent iodine atom with tosylate as a counter ion. The two reagents showed a broad range of synthetic applications and proved to be versatile oxidizing agents.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mulholland, Katie D. published the artcileIridium-catalysed 3,5-bis-borylation of phthalonitrile enables access to a family of C4h octaarylphthalocyanines, Safety of Phthalonitrile, the main research area is transition metal octaarylphthalocyanine complex preparation crystal structure; NMR spectra fluorescence transition metal octaarylphthalocyanine complex; preparation arylphthalonitrile crystal structure NMR spectra.

Ir-catalyzed borylation of phthalonitrile produces both 4-(Bpin)phthalonitrile (1) and 3,5-bis(Bpin)phthalonitrile (2), which are potential divergent intermediates for the synthesis of functionalized phthalocyanines. To exemplify the utility of 2, the authors prepared a series of 3,5-bis-arylphthalonitriles that in turn undergo sterically controlled regioselective cyclotetramization to give previously unknown C4h 1,3,8,10,15,17,22,24-octaarylphthalocyanines.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bori, Jugal published the artcileA new route for the synthesis of 2,4-bis(2-pyridyl)-6-(pyridyl)pyrimidines: Synthesis and characterization of Co(II), Ni(II) complexes of 2,4,6-tris(2-pyridyl)pyrimidine, HPLC of Formula: 100-70-9, the main research area is cobalt nickel pyridyl pyrimidine complex preparation crystal structure DFT; EPR spectra cobalt nickel pyridyl pyrimidine complex.

Using 2-acetylpyridine, sodium hydroxide and 2-cyanopyridine, 2,4,6-tris(2-pyridyl)pyrimidine (L1) was synthesized in good yield. Similarly, 2,4-bis(2-pyridyl)-6-(3-pyridyl)pyrimidine (L2) and 2,4-bis(2-pyridyl)-6-(4-pyridyl)pyrimidine (L3) were also synthesized by using resp. acetylpyridine. 2-Acetylpyridine reacted with sodium hydroxide to produce 2-oxo-2-(2-pyridyl)-1-ethanide, which behaves as a nucleophile towards 2-cyanopyridine. All three pyrimidines are potential multidentate ligand and by using L1 complexes of composition [Ni(L1)(H2O)3](NO3)2·4H2O (1), [Ni(L1)2](NO3)2·2H2O (2) and [Co(L1)2](NO3)2·1.5H2O (3) were isolated and structurally characterized. In 1-3, L1 behaves as a tridentate pincer type ligand, DFT calculations performed on L1-L3 indicate that energy difference between HOMO and LUMO is 4.544, 4.643 and 4.533 eV, resp.

Inorganica Chimica Acta published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Muley, Arabinda published the artcileHigh phenoxazinone synthase activity of two mononuclear cis-dichloro cobalt(II) complexes with a rigid pyridyl scaffold, SDS of cas: 100-70-9, the main research area is crystal structure cobalt bipyridine triazolylpyridine chloro; cobalt bipyridine triazolylpyridine preparation phenoxazinone synthase activity.

Phenoxazinone synthase (PHS) is a pentanuclear Cu enzyme studied for the last two decades, and though both Mn and Cu complexes were explored extensively, there are only a handful of reports on Co mononuclear moieties. In this regard, the authors have successfully synthesized two cis dichloro Co(II) mononuclear complexes Co(bpy)2Cl2:[1] and Co(L1)2Cl2:[2] with polypyridyl ligands (bpy = 2,2′-bipyridine, L1 = 2,2′-(1-methyl-1H-1,2,4-triazole-3,5-diyl)dipyridine) and thoroughly characterized them by different spectroscopic and anal. techniques such as FTIR, 1H NMR, UV-visible spectroscopy and ESI mass spectra. The mol. structures of 1 and 2 are elucidated by single-crystal x-ray diffraction studies. Spectral properties and redox behavior for 1-2 were examined The complexes show phenoxazinone synthase activity under ambient conditions and thorough examination of the acquired spectroscopic data imply excellent reactivity for both. Kinetic parameters for both the complexes are evaluated and the turnover numbers (kcat value) of these two complexes are 201.24 h-1 and 249.57 h-1 for 1 and 2, resp., which are quite high compared to those of previously reported similar complexes. The possible mechanistic route is also established with the help of mass spectroscopy and titrimetric anal. was performed to detect H2O2 that is a key intermediate formed in the catalysis and thus to prove the involvement of O2 in the oxidation This report offers an in-depth summary of metal ion involvement and the extent of the phenoxazinone synthase activity.

New Journal of Chemistry published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Galdeano, Carles published the artcileStructure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities, Application In Synthesis of 87150-13-8, the main research area is von Hippel Lindau protein ubiquitin ligase hypoxia inducible factor; crystal structure complex thiasole preparation.

E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-mol. ligands has been rewarded with limited success. The von Hippel-Lindau protein (pVHL) is the substrate recognition subunit of the VHL E3 ligase that targets HIF-1α for degradation The authors recently reported inhibitors of the pVHL:HIF-1α interaction, however they exhibited moderate potency. Herein, the authors report the design and optimization, guided by x-ray crystal structures, of a ligand series with nanomolar binding affinities.

Journal of Medicinal Chemistry published new progress about Crystal structure. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Application In Synthesis of 87150-13-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts