Month: November 2022

Biyiklioglu, Mack published the artcilePi-stacking interaction perphenazine modified zinc(II) phthalocyanine nanoparticles for photothermal and photodynamic therapy, Quality Control of 91-15-6, the main research area is perphenazine zinc phthalocyanine nanoparticle photothermal photodynamic therapy.

Photodynamic therapy and photothermal therapy as non-invasive treatment methods have been receiving more and more attention. The report shows that zinc(II) phthalocyanine (Pc2) modified by perphenazine forms nanoparticles with a particle size of 110 nm by π-π stacking in water. It has good photothermal effect when illuminated by 680 nm laser in aqueous solution In addition, its ability to produce active oxygen is 2.3-fold that of methylene blue, so Pc2 also has a good photodynamic effect. In vivo fluorescence shows that Pc2 has a good targeting effect on tumors. Under the synergistic effect of photodynamic therapy and photothermal therapy, Pc2 has good tumor inhibition efficiency.

Journal of Porphyrins and Phthalocyanines published new progress about Antitumor agents. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Quality Control of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ekineker, Gulcin published the artcileNewly axially silicon (IV) phthalocyanine photosensitizer: design, synthesis and photo-chemical properties, HPLC of Formula: 91-15-6, the main research area is silicon phthalocyanine photosensitizer design synthesis photochem property.

Phthalocyanines as used a photosensitizer in photodynamic therapy, phthalocyanines exhibit their long wavelength absorption and the ability to produce high singlet oxygen for tumor destruction with 650 to 900 nm fluorescence. In this study, new axially substituted silicon (IV) phthalocyanine (PS-4) was synthesized to determine photo-chem. properties using 2-methoxyethanol as an axial ligand to increase singlet oxygen quantum yield. Structural characterization of this new axially substituted silicon (IV) phthalocyanine were performed by IR, mass, 1H NMR and UV-Vis spectroscopic techniques. As axially substituted silicon (IV) phthalocyanine (PS-4) is thought to be a promising PDT agent, photo-chem. properties for cancer treatment with PDT have been investigated.

CBU Journal of Science published new progress about Antitumor agents. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Oekchuae, Sittisak published the artcileThe Design and Synthesis of a New Series of 1,2,3-Triazole-Cored Structures Tethering Aryl Urea and Their Highly Selective Cytotoxicity toward HepG2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is triazole cored aryl urea preparation antitumor human; 1,2,3-triazole-containing drug; click reaction; drug discovery; hepatocellular carcinoma (HCC); selective anti-HepG2 agent; sorafenib analog; targeted cancer drug.

Herein, a new series of 1,2,3-triazole-cored structures incorporating aryl urea I [R = H, 2-Me, 4-F, etc.] as anti-HepG2 agents was designed and synthesized via nucleophilic addition and copper-catalyzed azide-alkyne cycloaddition (CuAAC) with excellent yields. Significantly, almost all triazole-cored analogs exhibited less cytotoxicity toward normal cells, human embryonal lung fibroblast cell MRC-5, compared to Sorafenib and Doxorubicin. Among them, I [R = 2-OEt, 2-Cl] exhibited the highest selectivity indexes (SI = 14.7 and 12.2), which were ca. 4.4- and 3.7-fold superior to that of Sorafenib (SI = 3.30) and ca. 3.8- and 3.2-fold superior to that of Doxorubicin (SI = 3.83), resp. Addnl., excellent inhibitory activity against hepatocellular carcinoma HepG2, comparable to Sorafenib, was still maintained. A cell-cycle anal. and apoptosis induction study suggested that I [R = 2-OEt, 2-Cl] likely share a similar mechanism of action to Sorafenib. Furthermore, compounds I [R = 2-OEt, 2-Cl] exhibit appropriate drug-likeness, analyzed by SwissADME. With their excellent anti-HepG2 activity, improved selectivity indexes, and appropriate druggability, the triazole-cored analogs I [R = 2-OEt, 2-Cl] are suggested to be promising candidates for development as targeted cancer agents and drugs used in combination therapy for the treatment of HCC.

Pharmaceuticals published new progress about Antitumor agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Shuai published the artcileDesign, synthesis and biological evaluation of erythrina derivatives bearing a 1,2,3-triazole moiety as PARP-1 inhibitors, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is erythrina triazole preparation PARP 1 inhibitor antitumor structure activity; 1,2,3-Triazole; Apoptosis; Erythrina; PARP-1 inhibitor.

Inhibitors of poly (ADP-ribose) polymerase-1 (PARP-1) have shown to be promising in clin. trials against cancer, and many researchers are interested in the development of new PARP-1 inhibitors. Herein, we designed and synthesized 44 novel erythrina derivatives bearing a 1,2,3-triazole moiety, I (RR1 = O, R2 = H, 2-Me, 3-MeO, 4-Me, etc.; R = OH, R1 = H), as PARP-1 inhibitors. MTT assay results indicated that compound I (RR1 = O, R2 = 2-F) (II) had the most potent anti-proliferative activity against A549 cells among five cancer cells. The enzyme inhibitory activity in vitro of compound II was also significantly better than rucaparib. Furthermore, the selectivity index of compound II was higher than rucaparib for lung cancer cells. Flow cytometry anal. showed that compound II induced apoptosis of A549 cells by the mitochondrial pathway. Western blot anal. indicated that compound II was able to inhibit the biosynthesis of PAR effectively, and it was more potent than rucaparib. Also, compound II was able to up-regulate the ratio of bax/bcl-2, activate caspase-3, and ultimately induced apoptosis of A549 cells. The combined results revealed that the discovery of novel non-amide based PARP-1 inhibitors have great research significance and provide a better choice for the future development of drugs.

Bioorganic Chemistry published new progress about Antitumor agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhao, Xuan published the artcileA monoamine oxidase-A inhibitor phthalocyanine conjugate for targeted photodynamic therapy and inhibition of prostate cancer metastasis in vitro, Recommanded Product: Phthalonitrile, the main research area is preparation MAOA inhibitor phthalocyanine conjugate prostate cancer metastasis PDT.

Photodynamic therapy (PDT), as an alternative non-invasive clin. treatment modality, has been extensively employed for various anticancer applications in preclin. and clin. trials. However, there is hardly any PDT research based on invasive or metastatic tumors. But it can′t be ignored that cancer metastases are responsible for 90% of all cancer-related death. Among these metastatic cancers, prostate cancer (PCa) is regarded as one of the leading causes of cancer related deaths amongst male patients due to its high metastasis and high fatality rate. At present, it remains a great challenge to apply traditional PDT technol. for inhibiting prostate cancer metastasis. In this work, we successfully designed and synthesized a novel MAO-A targeted photosensitizer Pc-MLB for targeted photodynamic treatment of prostate cancer and inhibiting its metastasis in vitro. In vitro experiments demonstrate that Pc-MLB shows high target affinity and specificity towards prostate cancer cells and remarkable photodynamic anticancer activity compared with the control. More significantly, the migration and invasion assays show that Pc-MLB exhibits the ability to inhibit the migration and metastasis of prostate cancer cells to some extent.

Dyes and Pigments published new progress about Antitumor agents. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ertas, Merve published the artcilePotent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives, HPLC of Formula: 100-70-9, the main research area is antitumor agents ribonucleotide reductase inhibitors thiazole thiosemicarbazone ADME; antitumor agents; ribonucleotide reductase; thiazole; thiosemicarbazone.

The antioxidant, antimalarial, antibacterial, and antitumor activities of thiosemicarbazones have made this class of compounds important for medicinal chemists. In addition, thiosemicarbazones are among the most potent and well-known ribonucleotide reductase inhibitors. In this study, 24 new thiosemicarbazone derivatives were synthesized, and the structures and purity of the compounds were determined by IR, 1H NMR, 13C NMR, mass spectroscopy, and elemental anal. The IC50 values of these 24 compounds were determined with an assay for ribonucleotide reductase inhibition. Compounds 19, 20, and 24 inhibited ribonucleotide reductase enzyme activity at a higher level than metisazone as standard The cytotoxic effects of these compounds were measured on the MCF7 (human breast adenocarcinoma) and HEK293 (human embryonic kidney) cell lines. Similarly, compounds 19, 20, and 24 had a selective effect on the MCF7 and HEK293 cell lines, killing more cancer cells than cisplatin as standard The compounds (especially 19, 20, and 24 as the most active ones) were then subjected to docking experiments to identify the probable interactions between the ligands and the enzyme active site. The complex formation was shown qual. The ADME (absorption, distribution, metabolism, and excretion) properties of the compounds were analyzed using in-silico techniques.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Antitumor agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Girgis, Nabih S. published the artcilePhosphorus pentoxide in organic synthesis. VII. Synthesis of 3-aryl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-imines, Application of 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, the main research area is pyrrolopyrimidinimine aryl preparation antineoplastic; phosphorus pentoxide cyclization acetylaminopyrrolecarbonitrile; pyrrolecarbonitrile acetylamino phosphorus pentoxide cyclization; arylpyrrolopyrimidinimine preparation antineoplastic; fungicide arylpyrrolopyrimidinimine preparation; insecticide arylpyrrolopyrimidinimine preparation; plant regulator arylpyrrolopyrimidinimine preparation; pyrimidinimine arylpyrrolo antineoplastic preparation.

Anhydrous RR1C6H3NH2.HCl (R = H, R1 = H, 4-Cl, 2-F, 4-F, 3-Me, 4-Me, 4-Et, 4-Bu; R = 2-Cl, R1 = 4-Cl; R = 2-Me, R1 = 4-Me) reacted with pyrroles I [R2 = H, CHMeEt, CH2Ph; R3 = Me, Ph), P2O5, and N,N-dimethylcyclohexylamine at 150-180° to give the title compounds II, which were inactive against P388 lymphocytic leukemia. However, II (R = R1 = R2 = H, R3 = Me) was active against the plant louse, II (R = R2 = H, R1 = 4-F, R3 = Ph) was a plant regulator, and II (R = H, R1 = F, R2 = CHMeEt, R3 = Me) was a fungicide against Cercospora on peanut at 200 ppm.

Liebigs Annalen der Chemie published new progress about Antitumor agents. 59146-60-0 belongs to class nitriles-buliding-blocks, name is 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C6H7N3, Application of 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Zhanhui published the artcileDesign, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity, COA of Formula: C6H4N2, the main research area is pyrrolidine preparation antitumor metastatic activity lipophilicity antagonist; Antagonist; CXCL12; CXCR4; Chemokine; GPCR.

The design, synthesis and evaluation of novel CXCR4 antagonists were based on a pyrrolidine scaffold e.g., 3-(1,3-dioxolan-2-yl)-1-(3-methylpyridin-2-yl)propan-1one. The structural exploration/optimization identified numerous potent CXCR4 antagonists, represented by (S)-2-methyl-4-(4-methylpiperazin-1-yl)-6-((2-(3methylpyridin-2-yl)pyrrolidin-1-yl)methyl)pyrimidine, which displayed potent binding affinity to CXCR4 receptor (IC50 = 79 nM competitively displacing fluorescent 12G5 antibody) and inhibited CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). Moreover, in a transwell invasion assay, (S)-2-methyl-4-(4-methylpiperazin-1-yl)-6-((2-(3methylpyridin-2-yl)pyrrolidin-1-yl)methyl)pyrimidine significantly mitigated CXCL12/CXCR4 mediated cell migration. The (S)-2-Methyl-4-(4-methylpiperazin-1-yl)-6-((2-(3methylpyridin-2-yl)pyrrolidin-1-yl)methyl)pyrimidine exhibited good physicochem. properties (MW 367, logD7.4 1.12, pKa 8.2) and excellent in vitro safety profiles (e.g., hERG patch clamp IC50 > 30μM and minimal CYP isoenzyme inhibition). Importantly, (S)-2-methyl-4-(4-methylpiperazin-1-yl)-6-((2-(3methylpyridin-2-yl)pyrrolidin-1-yl)methyl)pyrimidine displayed much improved metabolic stability in human and rat liver microsomes. Lastly, (S)-2-Methyl-4-(4-methylpiperazin-1-yl)-6-((2-(3methylpyridin-2-yl)pyrrolidin-1-yl)methyl)pyrimidine demonstrated marked efficacy in a cancer metastasis model in mice. These results strongly support (S)-2-methyl-4-(4-methylpiperazin-1-yl)-6-((2-(3methylpyridin-2-yl)pyrrolidin-1-yl)methyl)pyrimidine as a prototypical lead for the development of promising CXCR4 antagonists as clin. candidates.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Boutard, Nicolas published the artcileDiscovery and structure-activity relationships of N-aryl 6-aminoquinoxalines as potent PFKFB3 kinase inhibitors, Application In Synthesis of 1885-29-6, the main research area is crystal structure neoplasm antitumor PFKFB3 kinase inhibitor aminoquinoxaline; cancer; enzymes; glycolysis; inhibitors; metabolism.

Energy and biomass production in cancer cells are largely supported by aerobic glycolysis in what is called the Warburg effect. The process is regulated by key enzymes, among which phosphofructokinase PFK-2 plays a significant role by producing fructose-2,6-biphosphate; the most potent activator of the glycolysis rate-limiting step performed by phosphofructokinase PFK-1. Herein, the synthesis, biol. evaluation and structure-activity relationship of novel inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which is the ubiquitous and hypoxia-induced isoform of PFK-2, are reported. X-ray crystallog. and docking were instrumental in the design and optimization of a series of N-aryl 6-aminoquinoxalines. The most potent representative, N-(4-methanesulfonylpyridin-3-yl)-8-(3-methyl-1-benzothiophen-5-yl)quinoxalin-6-amine, displayed an IC50 of 14 nM for the target and an IC50 of 0.49 μM for fructose-2,6-biphosphate production in human colon carcinoma HCT116 cells. This work provides a new entry in the field of PFKFB3 inhibitors with potential for development in oncol.

ChemMedChem published new progress about Antitumor agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lauria, Antonino published the artcileAnnelated pyrrolo-pyrimidines from amino-cyanopyrroles and BMMAs as leads for new DNA-interactive ring systems, Safety of 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, the main research area is sulfanylmethyleneamino ester aminocyanopyrrole heterocyclization; pyrrolopyrimidine preparation anticancer; imidazopyrrolopyrimidine preparation anticancer.

The efficient one-pot synthesis of several tricyclic systems, e.g., I, obtained from the reaction of substituted 2-amino-3-cyanopyrroles and 3-amino-4-cyanopyrroles with BMMAs, is reported. The duration and yields of the reaction strongly depend on the reactivity of the starting pyrrole and on the size of the ring to be formed. Mechanist features of the reaction were investigated and proposed by studying also the reactivity of a 3-aminopyrrole-2,4-dicyano substituted. The method reported represents an example of the use of BMMA reagents in combination with pyrrole derivatives and allowed an easy and versatile entry to a large number of pyrrolo-pyrimidines further annelated with nitrogen heterocycles of different sizes. These polycondensed heterocycles possessed the requisite to interact with DNA.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 59146-60-0 belongs to class nitriles-buliding-blocks, name is 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C6H7N3, Safety of 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts