Month: November 2022

On April 5, 2019, Chen, Yiyang; Lu, Ping; Wang, Yanguang published an article.Related Products of 2510-01-2 The title of the article was 3-Amino-fluorene-2,4-dicarbonitriles (AFDCs) as Photocatalysts for the Decarboxylative Arylation of α-Amino Acids and α-Oxy Acids with Arylnitriles. And the article contained the following:

1-(4-(9H-Carbazol-9-yl)phenyl)-3-amino-9H-fluorene-2,4-dicarbonitrile as a new photocatalyst for the decarboxylative cross-coupling reaction of α-amino acids or α-oxy carboxylic acids with arylnitriles is described. This light-driven reaction enables a variety of benzylic amines and ethers to be prepared from readily available starting materials under mild conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Related Products of 2510-01-2

The Article related to aminofluorene dicarbonitrile preparation photocatalyst decarboxylative arylation, arylation alpha amino acid oxy carboxylic acid arylnitrile, benzylic amine ether preparation cross coupling reaction and other aspects.Related Products of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 8, 2017, Menzies, Donna J.; Ang, Andrew; Thissen, Helmut; Evans, Richard A. published an article.Formula: C10H11N3O3S The title of the article was Adhesive Prebiotic Chemistry Inspired Coatings for Bone Contacting Applications. And the article contained the following:

New and improved bone-contacting medical devices are required to provide excellent bioactivity at the biointerface. Here, we have used coatings based on prebiotic chem. inspired polymerization of aminomalonitrile (AMN) in combination with comonomers 3,4-di- and 3,4,5-trihydroxybenzaldehyde (DHBA and THBA). The comonomers were incorporated into the AMN coatings to enhance polymerization kinetics, adhesive properties, metal binding efficacy, and human mesenchymal stem cell (hMSC) response. Incorporation of DHBA and THBA as sep. comonomers enhanced the polymerization kinetics compared to that of AMN polymerization alone, with 30 mol % THBA (30T) resulting in a 6-fold increase in thickness over 24 h. Furthermore, the adhesion of AMN coatings to silicon was enhanced when copolymerized with the HBA monomers, where the interfacial adhesion of the 30T coating was increased 20-fold. The ability of the coatings to incorporate zinc ions was investigated, and XPS anal. demonstrated that incorporating 30T increased the binding efficiency 4-fold compared to that of AMN alone. The attachment, proliferation, and morphol. of human mesenchymal stem cells (hMSC) on these coatings was investigated and reported. Finally, the utility of the coatings as osteogenic support matrixes via the induced osteogenic differentiation of hMSCs is reported. The AMN and 30T coatings resulted in the greatest efficiency of osteogenic differentiation, as measured by intracellular ALP activity and mineralization. Incorporation of zinc had a stimulatory effect on hMSC proliferation with 30T coatings, while enhanced mineralization was observed with the zinc functionalized AMN and 30T coatings. This study highlights the potential of prebiotic chem. inspired coatings in biomedical applications. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Formula: C10H11N3O3S

The Article related to adhesive prebiotic chem coating bone contacting application surface polymerization, adhesive coating, bioactive coatings, osteogenic differentiation, prebiotic chemistry, stem cells, universal coatings and other aspects.Formula: C10H11N3O3S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 21, 2003, Hirota, Kosaku; Kazaoka, Kazunori; Niimoto, Itaru; Sajiki, Hironao published an article.SDS of cas: 5098-14-6 The title of the article was Efficient synthesis of 2,9-disubstituted 8-hydroxyadenine derivatives. And the article contained the following:

An efficient and general method for the synthesis of 2,9-disubstituted 8-hydroxyadenines, e.g. I, which are expected to have various biol. activities, was realized. 5-Amino-4-cyano-2-hydroxyimidazoles, e.g. II, were prepared from aminomalononitrile and isocyanates as key intermediates. The condensation of II with amidines, imidates, guanidine, urea and thioureas afforded 8-hydroxyadenines, e.g. III, possessing various substituents at the 2-position. Furthermore, selective alkylation of 2-amino- and 2-hydroxyadenines (IV and V) successively proceeded to give the corresponding 2-alkylamino- and 2-alkoxyadenines, resp. 2-Alkylthioadenines, e.g. VI, were prepared by an analogous reaction of II with benzoyl isothiocyanate and subsequent S-alkylation. The imidazoles, e.g. II, are most useful intermediates for the synthesis of 8-hydroxyadenine derivatives The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).SDS of cas: 5098-14-6

The Article related to disubstituted hydroxyadenine adenine preparation condensation imidazole amidine imidate thiourea, alkoxyadenine alkylaminoadenine disubstituted adenine preparation alkylation hydroxyadenine aminoadenine and other aspects.SDS of cas: 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On November 30, 1979, Ferris, J. P.; Edelson, E. H.; Mount, N. M.; Sullivan, A. E. published an article.Synthetic Route of 5098-14-6 The title of the article was The effect of clays on the oligomerization of hydrocyanic acid. And the article contained the following:

The possible role of clays in prebiotic evolution was studied using the primitive Earth model in which aqueous solutions of HCN and diaminomaleonitrile (I) react with clay mineral sediments. The reaction of 0.1M HCN and dilute solutions of I at pH 8-9 and 25° in the presence of suspensions of montmorillonite (bentonite) clays were investigated. Montmorillonite clays inhibited the oligomerization of aqueous solutions of HCN. Yields of colored oligomers, urea, and I were all diminished by clays, but the rate of loss of cyanide was not significantly decreased. The inhibition of oligomer formation was due to the clay-catalyzed decomposition of I. The absence of strong binding of I to clays was suggested by the failure to detect I when a clay that was incubated with I was washed with spermidine (6 × 10-3 g/L). I did not simply bind to the clays as the bulk of radioactivity was recovered from the supernatant in the reaction of I-14C with montmorillonite. The clay-catalyzed decomposition of I was observed when montmorillonite from 2 different sources was used and with a variety of homoionic montmorillonites and bentonites. A modification of the established procedure for using the cyanide electrode for cyanide analyses was used to follow the release of HCN from I. This new method could be used in both the acidic and basic pH range and did not result in the destruction of I by the reagents used for the anal. Quant. anal. of the reaction solution from the clay-catalyzed decompositions of I revealed the formation of 1-2 equiv HCN/mol I. The possible significance of these clay-catalyzed reactions in prebiotic evolution is discussed. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Synthetic Route of 5098-14-6

The Article related to hydrocyanic acid polymerization clay, montmorillonite hydrocyanic acid polymerization, prebiotic evolution hydrocyanic acid polymerization clay, diaminomaleonitrile decomposition clay prebiotic evolution and other aspects.Synthetic Route of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 9, 2004, Chen, Ying-Chun; Xue, Dong; Deng, Jin-Gen; Cui, Xin; Zhu, Jin; Jiang, Yao-Zhong published an article.Recommanded Product: 2510-01-2 The title of the article was Efficient asymmetric transfer hydrogenation of activated olefins catalyzed by ruthenium amido complexes. And the article contained the following:

The asym. transfer hydrogenation of activated olefins, e.g., I, with chiral ruthenium amido complexes, using formic acid-triethylamine azeotrope as hydrogen source, resulted in aralkylmalononitriles, e.g., II, in excellent yields and high enantioselectivities. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2510-01-2

The Article related to arylidenemalononitrile asym transfer hydrogenation, aralkylmalononitrile preparation, ruthenium asym transfer hydrogenation catalyst, arylsulfonylaminodiphenylethylamine asym transfer hydrogenation ligand and other aspects.Recommanded Product: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 31, 2007, Hegab, Mohamed I.; Hassan, Nasser A.; Rashad, Aymn E.; Fahmy, Afaf A.; Abdel-Megeid, Farouk M. E. published an article.HPLC of Formula: 2510-01-2 The title of the article was Synthesis, Reactions, and Antimicrobial Activity of Some Fused Thieno[2,3-d]pyrimidine Derivatives. And the article contained the following:

Some new indeno[1′,2′ :4,5]thieno[2,3-d]pyrimidines were prepared from the reaction of 2-aminoindeno[2,1-b]thiophene-3-carbonitrile with different reagents. Also, some indeno[1′,2′:4,5]thieno[3,2-e]tetrazolo[1,5-c]pyrimidines and indeno[1′,2′ :4,5]thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidines and their isomeric [1,2,4]triazolo[1,5-c]pyrimidines were prepared The antimicrobial evaluation of some prepared products showed that many of them revealed promising antimicrobial activity. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).HPLC of Formula: 2510-01-2

The Article related to fused thieno pyrimidine derivative preparation antimicrobial activity, indeno thieno tetrazolo triazolo pyrimidine preparation antimicrobial activity, aminoindeno thiophene carbonitrile preparation reaction and other aspects.HPLC of Formula: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 28, 2007, Niess, Barbara; Joergensen, Karl Anker published an article.Recommanded Product: 2510-01-2 The title of the article was The asymmetric vinylogous Mannich reaction of dicyanoalkylidenes with α-amido sulfones under phase-transfer conditions. And the article contained the following:

The stereoselective vinylogous Mannich reaction of dicyanoalkylidenes under phase-transfer catalytic conditions utilizing stable α-amido sulfones as imine precursors is presented; a rigid pyrrolidinium salt acts as the phase-transfer catalyst, giving access to the amino alkylated products, e.g., I, in generally good yield and up to 95% ee. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2510-01-2

The Article related to amido sulfone dicyanoalkylidene chiral pyrrolidinium asym vinylogous mannich, aminoalkyl unsaturated dinitrile stereoselective preparation, asym vinylogous mannich phase transfer catalyst chiral pyrrolidinium and other aspects.Recommanded Product: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 8, 2020, Liao, Tzu-Ying; Easton, Christopher D.; Thissen, Helmut; Tsai, Wei-Bor published an article.Product Details of 5098-14-6 The title of the article was Aminomalononitrile-Assisted Multifunctional Antibacterial Coatings. And the article contained the following:

Medical device associated infections remain a significant problem for all classes of devices at this point in time. Here, we have developed a surface modification technique to fabricate multifunctional coatings that combine antifouling and antimicrobial properties. Zwitterionic polymers providing antifouling properties and quaternary ammonium containing polymers providing antimicrobial properties were combined in these coatings. Throughout this study, aminomalononitrile (AMN) was used to achieve one-step coatings incorporating different polymers. The characterization of coatings was carried out using static water contact angle (WCA) measurements, XPS, profilometry, and SEM, whereas the biol. response in vitro was analyzed using Staphylococcus epidermidis and Escherichia coli as well as L929 fibroblast cells. Zwitterionic polymers synthesized from sulfobetaine methacrylate and 2-aminoethyl methacrylate were demonstrated to reduce bacterial attachment when incorporated in AMN assisted coatings. However, bacteria in suspension were not affected by this approach. On the other hand, alkylated polyethylenimine polymers, synthesized to provide quaternary ammonium groups, were demonstrated to have contact killing properties when incorporated in AMN assisted coatings. However, the high bacterial attachment observed on these surfaces may be detrimental in applications requiring longer-term bactericidal activity. Therefore, AMN-assisted coatings containing both quaternary and zwitterionic polymers were fabricated. These multifunctional coatings were demonstrated to significantly reduce the number of live bacteria not only on the modified surfaces, but also in suspension. This approach is expected to be of interest in a range of biomedical device applications. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Product Details of 5098-14-6

The Article related to aminomalononitrile multifunctional antibacterial coating zwitterion biofouling quaternary ammonium, aminomalononitrile, biofouling, coating, contact-killing, quaternary ammonium compounds, zwitterionic polymer and other aspects.Product Details of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 15, 1989, Tian, Guan Rong; Sugiyama, Shigeru; Mori, Akira; Takeshita, Hitoshi published an article.Related Products of 2510-01-2 The title of the article was Synthetic photochemistry. XLVII. Formation and degenerate Cope rearrangement of 9-dicyanomethylenebarbaralane. And the article contained the following:

Photolysis of 2-dicyanomethylenehomobarrelene (I) gave 9-dicyanomethylenebarbaralane (II), 5-dicyanomethylenetricyclononadiene (III), and 1-dicyanomethyleneindan. II showed time-averaged NMR signals. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Related Products of 2510-01-2

The Article related to photolysis dicyanomethylenehomobarrelene, homobarrelene dicyanomethylene photolysis, degenerate cope rearrangement dicyanomethylenebarbaralane kinetics, barbaralane dicyanomethylene degenerate cope rearrangement and other aspects.Related Products of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 6, 1988, Matsuo, Masaaki; Tsuji, Kiyoshi; Konishi, Nobukiyo published a patent.Recommanded Product: 34662-29-8 The title of the patent was Phenoxy-substituted alkanesulfonanilide derivatives useful as analgesics, antiinflammatories, and antipyretics, and processess for their preparation. And the patent contained the following:

Title derivatives I [R1, R2, R8 = H, cyano, halo, alkyl, haloalkyl, alkythio, -sulfinyl, -sulfonyl, alkoxy; R3 = alkyl, mono- or dialkylamino; R4 = acyl, cyano, CO2H, hydroxyalkyl, SH, alkylthio, -sulfinyl, -sulfonyl, 2-oxodioxolan-3-ylidenemethyl, CR6:NR7, (un)substituted 5-membered unsaturated heterocyclyl; SPh; R5 = H, halo, alkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, ureido, thiouredo] are prepared for use as analgesics, antiinflammatories, and antipyretics. 4-Amino-3-(2,4-difluorophenoxy)acetophenone was prepared in 4 steps and sulfonylated by MeSO2Cl in pyridine to give acetyl(difluorophenoxy)methanesulfonanilide II. In the adjuvant arthritis test in rats, II at 1.0 mg/kg/day orally inhibited secondary (uninjected) paw lesion by 50%, vs. only 24.7% by ibuprofen at 10.0 mg/kg. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8

The Article related to phenoxyalkanesulfonanilide preparation analgesic antiinflammatory antipyretic, alkanesulfonanilide phenoxy preparation analgesic antiinflammatory, sulfonanilide phenoxyalkane preparation analgesic antiinflammatory and other aspects.Recommanded Product: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts