Month: November 2022

On November 30, 1979, Ferris, J. P.; Edelson, E. H.; Mount, N. M.; Sullivan, A. E. published an article.Synthetic Route of 5098-14-6 The title of the article was The effect of clays on the oligomerization of hydrocyanic acid. And the article contained the following:

The possible role of clays in prebiotic evolution was studied using the primitive Earth model in which aqueous solutions of HCN and diaminomaleonitrile (I) react with clay mineral sediments. The reaction of 0.1M HCN and dilute solutions of I at pH 8-9 and 25° in the presence of suspensions of montmorillonite (bentonite) clays were investigated. Montmorillonite clays inhibited the oligomerization of aqueous solutions of HCN. Yields of colored oligomers, urea, and I were all diminished by clays, but the rate of loss of cyanide was not significantly decreased. The inhibition of oligomer formation was due to the clay-catalyzed decomposition of I. The absence of strong binding of I to clays was suggested by the failure to detect I when a clay that was incubated with I was washed with spermidine (6 × 10-3 g/L). I did not simply bind to the clays as the bulk of radioactivity was recovered from the supernatant in the reaction of I-14C with montmorillonite. The clay-catalyzed decomposition of I was observed when montmorillonite from 2 different sources was used and with a variety of homoionic montmorillonites and bentonites. A modification of the established procedure for using the cyanide electrode for cyanide analyses was used to follow the release of HCN from I. This new method could be used in both the acidic and basic pH range and did not result in the destruction of I by the reagents used for the anal. Quant. anal. of the reaction solution from the clay-catalyzed decompositions of I revealed the formation of 1-2 equiv HCN/mol I. The possible significance of these clay-catalyzed reactions in prebiotic evolution is discussed. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Synthetic Route of 5098-14-6

The Article related to hydrocyanic acid polymerization clay, montmorillonite hydrocyanic acid polymerization, prebiotic evolution hydrocyanic acid polymerization clay, diaminomaleonitrile decomposition clay prebiotic evolution and other aspects.Synthetic Route of 5098-14-6

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 9, 2004, Chen, Ying-Chun; Xue, Dong; Deng, Jin-Gen; Cui, Xin; Zhu, Jin; Jiang, Yao-Zhong published an article.Recommanded Product: 2510-01-2 The title of the article was Efficient asymmetric transfer hydrogenation of activated olefins catalyzed by ruthenium amido complexes. And the article contained the following:

The asym. transfer hydrogenation of activated olefins, e.g., I, with chiral ruthenium amido complexes, using formic acid-triethylamine azeotrope as hydrogen source, resulted in aralkylmalononitriles, e.g., II, in excellent yields and high enantioselectivities. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2510-01-2

The Article related to arylidenemalononitrile asym transfer hydrogenation, aralkylmalononitrile preparation, ruthenium asym transfer hydrogenation catalyst, arylsulfonylaminodiphenylethylamine asym transfer hydrogenation ligand and other aspects.Recommanded Product: 2510-01-2

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Nitrile – Wikipedia,
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On July 31, 2007, Hegab, Mohamed I.; Hassan, Nasser A.; Rashad, Aymn E.; Fahmy, Afaf A.; Abdel-Megeid, Farouk M. E. published an article.HPLC of Formula: 2510-01-2 The title of the article was Synthesis, Reactions, and Antimicrobial Activity of Some Fused Thieno[2,3-d]pyrimidine Derivatives. And the article contained the following:

Some new indeno[1′,2′ :4,5]thieno[2,3-d]pyrimidines were prepared from the reaction of 2-aminoindeno[2,1-b]thiophene-3-carbonitrile with different reagents. Also, some indeno[1′,2′:4,5]thieno[3,2-e]tetrazolo[1,5-c]pyrimidines and indeno[1′,2′ :4,5]thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidines and their isomeric [1,2,4]triazolo[1,5-c]pyrimidines were prepared The antimicrobial evaluation of some prepared products showed that many of them revealed promising antimicrobial activity. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).HPLC of Formula: 2510-01-2

The Article related to fused thieno pyrimidine derivative preparation antimicrobial activity, indeno thieno tetrazolo triazolo pyrimidine preparation antimicrobial activity, aminoindeno thiophene carbonitrile preparation reaction and other aspects.HPLC of Formula: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 28, 2007, Niess, Barbara; Joergensen, Karl Anker published an article.Recommanded Product: 2510-01-2 The title of the article was The asymmetric vinylogous Mannich reaction of dicyanoalkylidenes with α-amido sulfones under phase-transfer conditions. And the article contained the following:

The stereoselective vinylogous Mannich reaction of dicyanoalkylidenes under phase-transfer catalytic conditions utilizing stable α-amido sulfones as imine precursors is presented; a rigid pyrrolidinium salt acts as the phase-transfer catalyst, giving access to the amino alkylated products, e.g., I, in generally good yield and up to 95% ee. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2510-01-2

The Article related to amido sulfone dicyanoalkylidene chiral pyrrolidinium asym vinylogous mannich, aminoalkyl unsaturated dinitrile stereoselective preparation, asym vinylogous mannich phase transfer catalyst chiral pyrrolidinium and other aspects.Recommanded Product: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 8, 2020, Liao, Tzu-Ying; Easton, Christopher D.; Thissen, Helmut; Tsai, Wei-Bor published an article.Product Details of 5098-14-6 The title of the article was Aminomalononitrile-Assisted Multifunctional Antibacterial Coatings. And the article contained the following:

Medical device associated infections remain a significant problem for all classes of devices at this point in time. Here, we have developed a surface modification technique to fabricate multifunctional coatings that combine antifouling and antimicrobial properties. Zwitterionic polymers providing antifouling properties and quaternary ammonium containing polymers providing antimicrobial properties were combined in these coatings. Throughout this study, aminomalononitrile (AMN) was used to achieve one-step coatings incorporating different polymers. The characterization of coatings was carried out using static water contact angle (WCA) measurements, XPS, profilometry, and SEM, whereas the biol. response in vitro was analyzed using Staphylococcus epidermidis and Escherichia coli as well as L929 fibroblast cells. Zwitterionic polymers synthesized from sulfobetaine methacrylate and 2-aminoethyl methacrylate were demonstrated to reduce bacterial attachment when incorporated in AMN assisted coatings. However, bacteria in suspension were not affected by this approach. On the other hand, alkylated polyethylenimine polymers, synthesized to provide quaternary ammonium groups, were demonstrated to have contact killing properties when incorporated in AMN assisted coatings. However, the high bacterial attachment observed on these surfaces may be detrimental in applications requiring longer-term bactericidal activity. Therefore, AMN-assisted coatings containing both quaternary and zwitterionic polymers were fabricated. These multifunctional coatings were demonstrated to significantly reduce the number of live bacteria not only on the modified surfaces, but also in suspension. This approach is expected to be of interest in a range of biomedical device applications. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Product Details of 5098-14-6

The Article related to aminomalononitrile multifunctional antibacterial coating zwitterion biofouling quaternary ammonium, aminomalononitrile, biofouling, coating, contact-killing, quaternary ammonium compounds, zwitterionic polymer and other aspects.Product Details of 5098-14-6

Referemce:
Nitrile – Wikipedia,
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On February 15, 1989, Tian, Guan Rong; Sugiyama, Shigeru; Mori, Akira; Takeshita, Hitoshi published an article.Related Products of 2510-01-2 The title of the article was Synthetic photochemistry. XLVII. Formation and degenerate Cope rearrangement of 9-dicyanomethylenebarbaralane. And the article contained the following:

Photolysis of 2-dicyanomethylenehomobarrelene (I) gave 9-dicyanomethylenebarbaralane (II), 5-dicyanomethylenetricyclononadiene (III), and 1-dicyanomethyleneindan. II showed time-averaged NMR signals. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Related Products of 2510-01-2

The Article related to photolysis dicyanomethylenehomobarrelene, homobarrelene dicyanomethylene photolysis, degenerate cope rearrangement dicyanomethylenebarbaralane kinetics, barbaralane dicyanomethylene degenerate cope rearrangement and other aspects.Related Products of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 6, 1988, Matsuo, Masaaki; Tsuji, Kiyoshi; Konishi, Nobukiyo published a patent.Recommanded Product: 34662-29-8 The title of the patent was Phenoxy-substituted alkanesulfonanilide derivatives useful as analgesics, antiinflammatories, and antipyretics, and processess for their preparation. And the patent contained the following:

Title derivatives I [R1, R2, R8 = H, cyano, halo, alkyl, haloalkyl, alkythio, -sulfinyl, -sulfonyl, alkoxy; R3 = alkyl, mono- or dialkylamino; R4 = acyl, cyano, CO2H, hydroxyalkyl, SH, alkylthio, -sulfinyl, -sulfonyl, 2-oxodioxolan-3-ylidenemethyl, CR6:NR7, (un)substituted 5-membered unsaturated heterocyclyl; SPh; R5 = H, halo, alkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, ureido, thiouredo] are prepared for use as analgesics, antiinflammatories, and antipyretics. 4-Amino-3-(2,4-difluorophenoxy)acetophenone was prepared in 4 steps and sulfonylated by MeSO2Cl in pyridine to give acetyl(difluorophenoxy)methanesulfonanilide II. In the adjuvant arthritis test in rats, II at 1.0 mg/kg/day orally inhibited secondary (uninjected) paw lesion by 50%, vs. only 24.7% by ibuprofen at 10.0 mg/kg. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8

The Article related to phenoxyalkanesulfonanilide preparation analgesic antiinflammatory antipyretic, alkanesulfonanilide phenoxy preparation analgesic antiinflammatory, sulfonanilide phenoxyalkane preparation analgesic antiinflammatory and other aspects.Recommanded Product: 34662-29-8

Referemce:
Nitrile – Wikipedia,
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Alizadeh, Abdolali; Sedighian, Hadi; Yasub Hosseini, Seyed; Zhu, Long-Guan published an article in 2015, the title of the article was Synthesis of Polysubstituted Benzenes via the Vinylogous Michael Addition of Alkylidenemalononitriles to 2-(1,3-Dioxo-1H-inden-2(3H)-ylidene)malononitrile.Product Details of 2510-01-2 And the article contains the following content:

An efficient synthesis for polysubstituted benzenes I [R1 = H; R1R2 = CH2CH2CH2, CH2CH2CH2CH2, etc.; R2 = C6H5, 4-H3CC6H4, chromen-2-one-3yl, etc.; R3 = CH3, CH2CH3] were successfully developed by the reaction of ninhydrin (2,2-dihydroxyindane-1,3-dione), malononitrile (propanedinitrile) and alkylidenemalononitrile. The method involves vinylogous Michael addition of alkylidenemalononitrile to 2-(1,3-dioxo-1H-inden-2(3H)-ylidene)malononitrile, which formed by condensation of malononitrile and ninhydrin in the presence of Et3N, and the alc. solvent has participated in the reaction as a reagent. The method has the advantages of good yields and of not requiring a metal catalyst. The structures were confirmed spectroscopically and in the case of compound I [R1R2 = -CH2CH2CH2CH2-; R3 = CH3], by X-ray crystallog. A plausible mechanism for this reaction is proposed. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Product Details of 2510-01-2

The Article related to malononitrile ninhydrin condensation triethylamine catalyst, dioxo indenylidene malononitrile preparation alkylidenemalononitrile vinylogous michael addition, polysubstituted benzene preparation and other aspects.Product Details of 2510-01-2

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Nitrile – Wikipedia,
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On May 5, 2008, Wang, Xiang-Shan; Wu, Jian-Rong; Li, Qing; Yao, Chang-Sheng; Tu, Shu-Jiang published an article.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was A novel and green method for the synthesis of indeno[2,1-c]pyridine derivatives in ionic liquid catalyzed by malononitrile. And the article contained the following:

1-Aryl-9H-indeno[2,1-c]pyridine-4-carbonitrile derivatives, e.g., I, were unexpectedly obtained from the reaction of 2-(2,3-dihydroinden-3-ylidene)malononitrile (II), aldehydes (such as 4-tolualdehyde), and malononitrile in ionic liquid at 90 °C. Modification of the novel reaction protocol resulted in a two-component reaction between II and aryl and heteroaryl aldehydes catalyzed by 10 mol% malononitrile. A 1,5-hydrogen transfer was proposed to occur in the formation of the product. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to dihydroindenylidene malononitrile aryl aldehyde malononitrile catalyst heterocyclization, aryl indenopyridine carbonitrile derivative preparation, ionic liquid green chem heterocyclization solvent and other aspects.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 25, 2002, Nakao, Kazunari; Okumura, Yoshiyuki; Matsumizu, Miyako; Uneo, Naomi; Hashizume, Yoshinobu; Kato, Tomoki; Kawai, Akiyoshi; Miyake, Yoriko; Nukui, Seiji; Shinjyo, Katsuhiro; Taniguchi, Kana published a patent.Recommanded Product: 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of imidazoarenes as antiinflammatory and analgesic agents.. And the patent contained the following:

Title compounds [I; Y1-Y4 = N, CH, CL; R1 = H, (substituted) alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, pyrrolidinyl, amino, etc.; A = (substituted) 5-6 membered monocyclic aromatic ring optionally containing up to 3 heteroatoms selected from O, N, S, etc.; B = halo-substituted alkylene, cycloalklylene, alkenylene, alkynylene, alkyleneoxy, etc., optionally substituted with an oxo group; W = amino, O, S, bond, etc.; R2 = H, OH, alkyl, alkoxy; Z = 5-12 membered (substituted) monocyclic or bicyclic aryl optionally containing up to 3 heteroatoms selected from O, N and S, etc.; L = halo, alkyl, haloalkyl, OH, alkoxy, haloalkoxy, alkylthio, NO2, amino, etc.], were prepared as prostaglandin E2 receptor antagonists, preferably as EP4 receptor antagonists. Thus, to 2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethylamine (preparation given) in CH2Cl2 was added p-toluenesulfonyl isocyanate followed by stirring for 3 h to give 56% 2-ethyl-5,7-dimethyl-3-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-3H-imidazo[4,5-b]pyridine. Preferred I inhibited PGE2-induced thermal hyperalgesia in rats with ED50<60 mg/kg. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 3-Chloro-4-nitrobenzonitrile

The Article related to imidazoarene preparation antiinflammatory analgesic, prostaglandin receptor antagonist imidazoarene preparation, benzimidazole imidazopyridine preparation ep4 antagonist analgesic antiinflammatory and other aspects.Recommanded Product: 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts