Uruma, Yoshiyuki published the artcileSynthesis and biological evaluation of glucose conjugated phthalocyanine as a second-generation photosensitizer, Synthetic Route of 91-15-6, the main research area is glucose conjugated phthalocyanine preparation PDT photosensitizer cancer; Glucose; Hypoxia; Near-infrared (NIR) irradiation; Photodynamic therapy (PDT); Photosensitizers (PSs); Phthalocyanine (Pc).
Photodynamic therapy (PDT) is a treatment method using light and photosensitizers (PSs), which is categorized as a non-invasive surgery treatment for cancers. When the tumor is exposed to a specific light, the PSs become active and generate reactive oxygen species (ROS), mainly singlet oxygen which kills nearby cancer cells. PDT is becoming more widely recognized as a valuable treatment option for localized cancers and pre-cancers of skin as it has no long-term effects on the patient. But, due to the limited penetration rate of light into the skin and other organs, PDT can’t be used to treat large cancer cells or cancer cells that have grown deeply into the skin or other organs. Hence, in this study, our focus centers on synthesizing glucose-conjugated phthalocyanine (Pc) compatible with near-IR (NIR) irradiation as second-generation photosensitizer, so that PDT can be used in a wider range to treat cancers without obstacles.
Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts