Saul, Sirle published the artcileIdentification and evaluation of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV), Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is anilinoquinoline anilinoquinazoline antiviral dengue virus Venezuelan equine encephalitis virus; Alphavirus; Antiviral; Dengue virus; Flavivirus; Venezuelan equine encephalitis virus.
There is an urgent need for novel strategies for the treatment of emerging arthropod-borne viral infections, including those caused by dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV). We prepared and screened focused libraries of 4-anilinoquinolines and 4-anilinoquinazolines for antiviral activity and identified three potent compounds N-(2,5-dimethoxyphenyl)-6-(trifluoromethyl)quinolin-4-amine (10, I) inhibited DENV infection with an EC50 = 0.25μM, N-(3,4-dichlorophenyl)-6-(trifluoromethyl)quinolin-4-amine (27, II) inhibited VEEV with an EC50 = 0.50μM, while N-(3-ethynyl-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine (54, III) inhibited VEEV with an EC50 = 0.60μM. These series of compounds demonstrated nearly no toxicity with CC50 values greater than 10μM in all cases. These promising results provide a future prospective to develop a clin. compound against these emerging viral threats.
Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts