Saito, Tetsuji published the artcile6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists, HPLC of Formula: 170737-93-6, the main research area is cyclopentapyrazolopyrimidine derivative preparation corticotropin releasing factor antagonist SAR pharmacokinetic.
To identify an orally active corticotropin-releasing factor 1 receptor antagonist, a series of 6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives were designed, synthesized and evaluated. An in vitro study followed by in vivo and pharmacokinetic studies of these heterotricyclic compounds led to the discovery of an orally active CRF1 receptor antagonist, I. The results of a structure-activity relationship study are presented.
Bioorganic & Medicinal Chemistry published new progress about Anxiety disorders. 170737-93-6 belongs to class nitriles-buliding-blocks, name is 2-(2-Chloro-4-methoxyphenyl)acetonitrile, and the molecular formula is C9H8ClNO, HPLC of Formula: 170737-93-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts