Hwu, Jih Ru published the artcileSynthesis and antiviral activities of quinazolinamine-coumarin conjugates toward chikungunya and hepatitis C viruses, HPLC of Formula: 1885-29-6, the main research area is quinazolinamine coumarin preparation antiviral chikungunya hepatitis C virus; Broad-spectrum; Chikungunya virus; Coumarin; Hepatitis C virus; Quinazolin-4-amine; Structure–activity relationship.
Development of new drugs with broad-spectrum to combat RNA viruses would be beneficial to mankind but faces a great challenge. Authors designed and efficiently synthesized a series of quinazolin-4-amine-SCH2-coumarin conjugated compounds Authors data of the virus-cell-based assay show five new conjugates inhibit chikungunya virus with EC50 values as potent as 1.96μM and two conjugates inhibit hepatitis C virus with EC50 values as low as 16.6μM. These conjugates possess a xylene substituent at the C-4 amino group of quinazoline and a t-Bu substituent at the C-6′ position of coumarin.
European Journal of Medicinal Chemistry published new progress about Antiviral agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts